Date of Award

Fall 12-12-2017

Degree Type

Project

Degree Name

Master of Science (MS)

Department

Nutrition

First Advisor

Anita Nucci

Second Advisor

Barbara Hopkins

Abstract

Intestinal failure is characterized by malnutrition, malabsorption, and growth retardation. The most common cause of intestinal failure is short bowel syndrome. If the remaining bowel is unable to adapt to allow weaning from parenteral nutrition and achievement of enteral autonomy, then intestinal transplantation should be considered. Energy and macro- and micronutrient intakes are closely monitored pre-transplant to optimize nutrition prior to surgery. Few studies have been conducted to examine the nutritional requirements and nutritional status post-transplant. Of the studies that have been done, results have been inconsistent. The purpose of this review is to summarize the current literature related to nutrition requirements and growth after pediatric intestinal transplant. Monitoring of vitamin and mineral status is also essential in ensuring proper growth and preventing deficiencies post-transplant. Five out of six studies showed a positive growth trend at the one-year mark post-transplant. One study showed that children with a weight and height z-score of less than -2.0 had a faster catch-up growth post-transplant. Other studies reported positive growth progression within the first two years after transplant. There is still a great deal of information unknown about nutrition and growth post-transplant. Further studies need to be conducted to determine if and how nutrition requirements change post-transplant.

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