Increased CNV-Region Deletions in Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) Subjects in the ADNI Sample
We investigated the genome-wide distribution of CNVs in the Alzheimer's disease (AD) Neuroimaging Initia- tive (ADNI) sample (146 with AD, 313 with Mild Cognitive Impairment (MCI), and 181 controls). Comparison of single CNVs between cases (MCI and AD) and controls shows overrepresentation of large hetero- zygous deletions in cases (p-value b 0.0001). The analysis of CNV-Regions identiﬁes 44 copy number variable loci of heterozygous deletions, with more CNV-Regions among affected than controls (p = 0.005). Seven of the 44 CNV-Regions are nominally signiﬁcant for association with cognitive impairment. We validated and con- ﬁrmed our main ﬁndings with genome re-sequencing of selected patients and controls. The functional pathway analysis of the genes putatively affected by deletions of CNV-Regions reveals enrichment of genes implicated in axonal guidance, cell–cell adhesion, neuronal morphogenesis and differentiation. Our ﬁndings support the role of CNVs in AD, and suggest an association between large deletions and the development of cognitive impairment.
Guffanti G, Torri F, Rasmussen J, Clark AP, Lakatos A, Turner JA, Fallon JH, Saykin AJ, Weiner M; ADNI the Alzheimer's Disease Neuroimaging Initiative, Vawter MP, Knowles JA, Potkin SG, Macciardi F.. Increased CNV-Region Deletions in Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) Subjects in the ADNI Sample. Genomics. 2013 Aug;102(2):112-22. doi: http://dx.doi.org/10.1016/j.ygeno.2013.04.004
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Genomics. 2013 Aug;102(2):112-22. doi: http://dx.doi.org/10.1016/j.ygeno.2013.04.004