Date of Award
5-15-2008
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Psychology
First Advisor
Dr. Andrew Clancy - Chair
Second Advisor
Dr. Thomas Wichmann - Co-Chair
Third Advisor
Dr. Kyle Frantz
Abstract
In the present study, electrophysiological and behavioral effects of compromised Gama-Aminobutyric Acid (GABAergic) transmission were investigated in adult Rhesus macaque monkeys (N=2). GABAergic transmission was perturbed in the putamen by administration of a GABAa receptor antagonist, gabazine (10 and 500 μM), via a microdialysis-local field potential (MD-LFP) probe. Resultant changes in striatal local field potentials (LFPs) were measured as an assay of synchrony. Gabazine perfusion evoked discrete large amplitude spikes in LFPs in all subjects, and the frequency and shape of individual spikes were concentration-dependent. Pre-treatment with the GABAa receptor agonist, muscimol (100 μM) blocked the gabazine-induced events, confirming a role for GABAa receptors in the effects. Behavioral manifestations of gabazine treatment were observed only at the maximum concentration. Unusual facial movements suggested aberrant electrical activity was propagated from striatum to motor cortex, perhaps via reentrant circuits. These results support a role for GABAergic transmission in segregation of striatal circuits.
DOI
https://doi.org/10.57709/1062332
Recommended Citation
Seiscio, Andrew R., "The Role of GABAergic Transmission in Mediation of Striatal Local Field Potentials (LFPs)." Thesis, Georgia State University, 2008.
doi: https://doi.org/10.57709/1062332