Date of Award

5-5-2008

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Lucjan Strekowski - Chair

Second Advisor

A.L. Baumstark

Third Advisor

Gabor Patonay

Fourth Advisor

Doyle Barrow

Abstract

The synthesis of a series of 2-chloropyrimidine derivatives is described. The synthesis began with a nucleophilic addition of lithiated heterocyclic molecules to the 4 position of 2-chloropyrimidine to give dihydropyrimidine intermediates. The intermediates were oxidized to the pyrimidine ring using the DDQ method. This was followed by an addition-elimination reaction of an amine to the 2-chloropyrimidine derivative. The structure and properties of the final compounds were analyzed by melting point, combustion analysis, and 13C-NMR and 1H-NMR spectroscopy. Biological activities in vitro of the synthesized compounds as antagonists of the 5-HT2a and 5-HT7 receptors were determined by an independent laboratory.

Share

COinS