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Dissertations from 2024

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Regulations and Mechanisms of Anaerobic Aromatic Hydrocarbon Oxidation in Geotalea daltonii strain FRC-32, James Bullows

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A Temporal Analysis of Acute Cadmium Exposure in Saccharomyces cerevisiae, Margaret Creech

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Evolution-Guided Engineering of Elongation Factor-Tu for Incorporation of Non-Canonical Amino Acids, Lanqiao Xiong

Dissertations from 2023

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The Critical Role of Interleukin-6 in Protection against Neurotropic Flavivirus Infection, Tabassum Tasnim Auroni

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Chronic Exposure to Low Molecular Weight Polycyclic Aromatic Hydrocarbons Promotes Metabolic Inflammation in Vertebrate and Invertebrate Systems, Asia S. Bright

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Machine Learning Approaches to Predict Neoadjuvant Chemotherapy Response and Metastasis in Women with Triple-Negative Breast Cancer Based on Tumor Microenvironments, Timothy Fisher

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SUMOylation as a modulator of ion channel function and expression, Leslie-Anne R. Jansen

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The TET family proteins regulate skeletal muscle fiber type determination and whole-body energy homeostasis., Miranda Movahed

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A Novel Role of Histone Methyltransferase SMYD2 in Atherosclerosis and Plaque Calcification, Shaligram Sharma

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Peripheral Sympathetic Leptin Receptor Signaling Regulates Sympathetic Innervation of White Adipose Tissue and Diet-Induced Thermogenesis, Felipe C. Silva

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Investigation into Metabolism and Signaling of Hemoglobin in Streptococcus pneumoniae, Edroyal Womack

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Discovering Novel Therapeutics for Triple Negative Breast Cancer, Lihan Zhao

Dissertations from 2022

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Adjuvant Effects on Enhancing Influenza Vaccine Effectiveness and Heterologous Prime-Boost Influenza Vaccination Strategy, Noopur Bhatnagar

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Inhibition of FAK-Actin pathway by indoxyl sulfate suppresses arteriogenesis in a mouse model of chronic kidney disease, Sean Carr

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Analysis of Molecular Interactions Between West Nile Virus and Host Cells, Emilio Espinola Estigarribia

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Systemic Administration of PKM2 Preserves Cardiomyocytes and Reduces Cardiac Fibrosis During Myocardial Infarction, Yang Huang

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Evaluation Of Prognostic Role Of Kinesin Family Member C1 And Its Downstream Molecular Partners In Aggressive Breast Cancer Subtypes, Shriya P. Joshi

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Multi-omics Approaches to Study Triple-Negative Breast Cancer Metastasis, Jaspreet Kaur

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Neuropathogenesis of SARS-CoV-2 Infection in Mice, Pratima Kumari

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Investigations On The Pathogenesis Of Herpesvirus Retinitis In Mice During Retrovirus-induced Immunosuppression, Jay Oh

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Epigenetic Regulation of Brown Fat Thermogenesis and Hepatic Lipid Metabolism by DNA Methylation, Shirong Wang

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Angiogenesis and Endothelial Dysfunction: Insights of Autophagy Machinery in Regulating Endothelial cell Biology, Hongmin Yao

Dissertations from 2021

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Crystallographic and enzyme kinetics studies of multidrug resistant HIV-1 protease mutants PR20 and PRS17., Shelley Burnaman

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Immobilization of Enzymes from Rhodococcus Rhodochrous DAP 96253 with Targeted Uses for the Bioconversion of Acrylonitrile to Bioacrylamide and for the Novel Therapeutic Treatment of Acute Lymphoblastic Leukemia, Brianna RG Chilton

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Evaluation of Novel Druggable Targets and Mechanism of Action in Breast and Prostate Cancer, Chakravarthy Garlapati

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The Role of Signal Regulatory Protein Alpha in Hemophagocytic and Cytokine Storm Syndromes, Koby Kidder

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Protein interactions with heme are vital for pathogenic bacteria, particularly in the utilization of heme as an iron source, Kristin V. Lyles

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Beyond Glycolysis: Pyruvate Kinase M2 Regulates Cancer Cell Glutaminolysis And Macrophage Polarization, Guangda Peng

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Double-Layered M2e-NA Nanoparticles Induce Broad Protection Against Different Influenza Viruses in Mice, Ye Wang

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Post-translational SUMOylation dynamically regulates voltage-gated potassium channel, Kv4.2, Meghyn Welch

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Central Respiratory Depression: Insight With Murine Models Of Rett Syndrome And Morphine Overdose, Hao Xing

Dissertations from 2020

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Hemoglobin and the Host Pathogen Interactions in Streptococcus pneumoniae: a New Paradigm, Fahmina Akhter

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Preliminary Report on Protein Preparations Exhibiting Both Asparaginase and Glutaminase Activity Purified from Rhodococcus Rhodochrous DAP 96253, Nosazena Amadasun

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Prognostic and Predictive Biomarkers in Breast Cancer, Shristi Bhattarai

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Inferences of Glia-Mediated Control in Caenorhabditis elegans, Stephanie Bowles

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Rhamnus prinoides Plant Extracts and Pure Compounds Inhibit Microbial Growth and Biofilm Formation, Mariya Campbell

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The Role of Pyroptosis and Associated Inflammasomes during Experimental Cytomegalovirus Retinitis, Jessica Carter

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Heme Uptake in Group A Streptococcus: A Role in Physiology and Disease, Nilanjana Chatterjee

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Melanocortin-3 Receptor-Expressing Neurons of The Ventral Tegmental Area: Anatomy and Regulation of Feeding and Body Weight, Anna I. Dunigan

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Functions of Extracellular Pyruvate Kinase M2 in Fibrosis-related Diseases, Hongwei Han

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Microbial Bioconversion of Polypropylene by Yarrowia Lipolytica: Enhancing Bioconversion and Lipogenesis through Optimization of Fermentation Parameters, Merhawi Mihreteab

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IL-36R Signaling and Gut Immunity, Vu Ngo

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RNA Helicase DDX5 Regulates Platelet Derived Growth Factor Receptor β and Androgen Receptor (AR) Expression in Breast Cancer, Neha Panchbhai

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Dimer Pyruvate Kinase M2 Regulates de novo Collagen Synthesis and Crosslinking in Pathological Fibrosis, Ganesh Satyanarayana

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Therapeutic Targeting Of Stroma Decreases Tumor Progression And Restores Chemosensitivity, Malvika Sharma

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B Virus Neutralization And Specific Antibody Induction: Each Dependent On Unique Glycoprotein B Epitopes., Vishakh Walia

Dissertations from 2019

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Role of Microbiome in Impacting Treatment of Obesity and Type 2 Diabetes, Aneseh Adeshirlarijaney

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Role of Notch1 in acute colitis and colitis associated cancer, Adani Pujada Alcala

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Approaches forPurifying Recombinant Proteins from Gram Negative Bacteria, Susan Burran

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An Approach to Optimization of Whole-Cell Catalyst Rhodococcus rhodochrous DAP 96253 Production for Mold Control and as a Therapeutic, Kelly Cannon

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Pre-pilot Fed-batch Fermentation of Rhodococcus rhodochrous DAP 96253 with Emphasis on Production of Therapeutic Enzymes and Post-harvest Agricultural Applications, Maurice de la Croix

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Histone Deacetylase-linked Repression and Metabolically-linked Derepression of Adenovirus Persistent Infection of Lymphocytes, Megan Dickherber

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Identification of Novel Druggable Targets in Two Members of Mononegavirales, Venice DuPont

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The Role of CD98 in Dysregulation of MiRNA and Protein Expression Along the Villus-Crypt Axis in Intestinal Epithelium, Moon Han

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Identification and Treatment of Autonomic Dysfunction in Rett Syndrome Mouse Models, Christopher Johnson

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Machine Learning Approaches to Predict Recurrence of Aggressive Tumors, Sergey Klimov

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X-Ray Crystal Structures And Enzyme Kinetic Investigations Of Drug-Resistant Mutants Of Hiv-1 Protease, Daniel Walter Kneller

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Bioinformatics Techniques for Studying Drug Resistance In HIV and Staphylococcus Aureus, Shrikant Pawar

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Biochemical Characterization of the Flavivirus-resistance Mouse ABCF3 Protein and a Review of the Antibiotic Resistance and Dissemination Mechanisms in Bacteria, Elizabeth A. Peterson

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Dynamic regulation of CD4+ regulatory T cells by radiation treatment, Samantha Simon

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Microbiota-Immune System Interactions in Diet-Induced Metabolic Syndrome, Hao Tran

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Structural & Enzymatic Studies on HIV-1 Protease Drug Resistance: Mutation L76V & Combination with Additional Resistance Mutations, Andres Wong-Sam

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Actionable Biology and Prognostic Biomarkers in Breast Cancer Patients of African Descent, Nikita Wright

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Exploring Alternative Antiviral Therapeutic Strategies Through Immunomodulation and Learning Novel Innate Immune Responses Against Rotavirus Infection, Zhan Zhang

Dissertations from 2018

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Dynamic Regulation Of The Bone Marrow Myeloid Compartment Under Post-Acute/Chronic Inflammatory Conditions, Courtney Culpepper

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Development And Implementation Of Genetics Modules For Young Learners, Michelle V. Ezeoke

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Effects of Vaccine Platforms and Adjuvants on Protective Efficacy against Human Respiratory Syncytial Virus, Youri Lee

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Epigenetic Regulation of Brown Fat Thermogenesis, Fenfen Li

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Characterization Of Flavivirus Disease Resistance In Mice And Comparative Analysis Of Infections With Pathogenic And Non-Pathogenic Strains Of West Nile Virus In Pluripotent Stem Cell-Derived Central Nervous System Cells, Joseph C. Madden Jr

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Clinical and Translational Implications of Centrosome Amplification and Clustering in Multiple Malignancies, Karuna Mittal

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Substrate Binding and Energy Transduction in a Multidrug Resistance ABC Transporter DrrAB, Sadia J. Rahman

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Production, purification, and process development of recombinant flagellin vaccine platform in Escherichia coli, Joshua Renfroe

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Novel role of the central unstructured Paramyxovirus nucleopcapsid protein tail domain, Vidhi Deepak Thakkar

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Ghrelin Regulates Energy Homeostasis Through Discrete Central and Peripheral Signaling Mechanisms, Michael Alex Thomas

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The Novel Tumor Supressive Role of Epithelial-Derived Matrix Metalloproteintase 9 In Colitis Associated Cancer, Lewins Walter

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Cellular And Molecular Insight Into Autonomic Function And Dysfunction, Yang Wu

Dissertations from 2017

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Suppressor of Cytokine Signaling (SOCS)1 and SOCS3 Stimulation during Experimental Cytomegalovirus Retinitis: Virologic, Immunologic, or Pathologic Mechanisms, Christine I. Alston

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Symbiont-Produced Byrostatins: Investigation of their Biosynthesis and Effects on Host Target, Kayla I. Bean

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Illuminating Actionable Biology in Breast Cancer: Novel Predictive and Prognostic Biomarkers, Angela Ogden Bellos

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Computational Interrogation of Transcriptional and Post-Transcriptional Mechanisms Regulating Dendritic Development, Surajit Bhattacharya

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Regulation of Nontypeable Haemophilus Influenzae-Induced Inflammation in Upper Respiratory Tract, Ashley Bohn

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Transcriptional Regulation of Factors Required for The Differentiation of Gabaergic Motor Neurons in the Developing Ventral Nerve Cord of Caenorhabditis Elegans, Richard F. Campbell

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Analysis of a Non-canonical Antiviral Mechanism in West Nile Virus-infected Mouse Cells, Dan Cui

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Biomimicry of Volatile-Based Microbial Control for Mitigating Fungal Pathogenicity, Kyle T. Gabriel

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Gene Regulation Pathways Affect Toxin Gene Expression, Sporulation and Pigment Generation in Bacillus Anthracis and Bacillus Cereus, Hesong Han

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Cross-protection Mechanisms of Influenza Virus Vaccines, Yu-Jin Kim

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Lipid Utilization of Pseudogymnoascus Destructans and Accompanying Physiological Factors that Influence White-Nose Syndrome, John Neville

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Central Control Of Body Fat And Thermoregulation Through Shared And Separate Sympathetic Circuitries And Sensory Feedback, Ngoc Ly Nguyen

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Regulation Of Innate Immune Cell Response Under Sub-acute/Chronic Inflammatory Conditions, Shuo Niu

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Ion Channel SUMOylation: a Novel Role for SUMO in Homeostatic Regulation of Multiple Ionic Conductances, Anna Parker

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Decoding the Sympathetic Nervous System's Regulation of White Adipose Tissue Hyperplasia, Mary K. Schneider

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Reprogramming of Myeloid Compartments Supporting Tissue Repair During Dss-Induced Colitis Recovery, Alexandra Tremblay

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PROAGIO (A Protein Designed to Target Integrin αVβ3), Ravi C. Turaga

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Development & Expression Of A Novel Synthetic Flagellin Fusion Protein Containing A Shigella Toxoid Subunit As A Potential Vaccine Against Shigellosis & Stec, Carlos Vazquez

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Adenovirus ?Hit-And-Run? Eviction From B-Cells Harboring Leukemic Runx1 Fusion Genes And Adp Controlled Latency In Lymphocytes, Hans T. Wilms

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Intervention to Extrasynaptic Gabaa Receptors for Symptom Relief in Mouse Models of Rett Syndrome, Weiwei Zhong

Dissertations from 2016

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The Regulation of Nontypeable Haemophilus influezae-Induced Inflammation and an Alternative Therapeutic Strategy, Carla S. Andrews

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Process Improvements to Fed-batch Fermentation of Rhodococcus rhodochrous DAP 96253 for the Production of a Practical Fungal Antagonistic Catalyst, Courtney Barlament

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The Role of MAPK P38 Stress Pathway-Induced Cellular Translation in Human and Macaque Cells Targeted during B Virus Infection, Morgan Cook

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Characterization of Simian Hemorrhagic Fever Virus Subgenomic RNAs and Proteins, Han Di