Author ORCID Identifier


Date of Award

Winter 12-13-2023

Degree Type


Degree Name

Master of Interdisciplinary Studies (MIS)


Biomedical Sciences

First Advisor

Baozhong Wang

Second Advisor

Lanying Du


Influenza remains a major global health issue, demanding the need for more effective vaccine strategies. This thesis searches into a novel approach, employing cell-derived extracellular vesicles (EVs) to boost influenza vaccine effectiveness. It dives into the impact of EVs on the innate immune system and their role on a cellular basis. Using cell culture and in vitro immune assays, the composition and immunomodulatory traits of EVs from antigen-presenting cells are researched. The study systematically examines the interactions between these EVs and key components of the innate immune system, unveiling the mechanisms driving their immunostimulatory effects. This research yields crucial insights into EVs' potential as immunomodulators in influenza vaccines. Additionally, determining insights into the identification and validation of adjuvants that enhance EV-mediated immune responses marks a pivotal stride toward the advancement of novel influenza vaccines, increasing their efficacy and protection against diverse viral strains.


Available for download on Thursday, May 30, 2024