Author ORCID Identifier
Date of Award
Master of Interdisciplinary Studies (MIS)
Influenza remains a major global health issue, demanding the need for more effective vaccine strategies. This thesis searches into a novel approach, employing cell-derived extracellular vesicles (EVs) to boost influenza vaccine effectiveness. It dives into the impact of EVs on the innate immune system and their role on a cellular basis. Using cell culture and in vitro immune assays, the composition and immunomodulatory traits of EVs from antigen-presenting cells are researched. The study systematically examines the interactions between these EVs and key components of the innate immune system, unveiling the mechanisms driving their immunostimulatory effects. This research yields crucial insights into EVs' potential as immunomodulators in influenza vaccines. Additionally, determining insights into the identification and validation of adjuvants that enhance EV-mediated immune responses marks a pivotal stride toward the advancement of novel influenza vaccines, increasing their efficacy and protection against diverse viral strains.
Bruhn, Madeline, "The Effects of Cell-Derived Extracellular Vesicles on the Innate Immune System." Thesis, Georgia State University, 2023.
Available for download on Thursday, May 30, 2024