Date of Award

8-7-2018

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Suazette Mooring

Second Advisor

Donald Hamelberg

Third Advisor

Jeremiah Harden

Abstract

Chemokines, largest family of cytokines, regulate cell trafficking through interaction of GPCR. Chemokines are classified into categories depending on the pattern of cysteine residue. Chemokine receptor type 4 (CXCR4) is a cell surface receptor important when cells migrate during inflammation and has been linked to various disease pathways such as cancer metastasis, inflammation disease, HIV-1 proliferation, and auto-immune disorders. CXCR4 along with its cognate ligand CXCL12 have been projected to regulate metastases sites in invasion of breast cancer cells. Several pyridine analogues have been synthesized as potential CXCR4 antagonists via reductive amination. These compounds are analyzed through proton and carbon NMR, high- resolution mass spectrometry, and melting point. After synthesis, the analogues undergo several assays at Emory University in Shim lab. The assays include Binding affinity assay, Matrigel invasion assay, and Carrageenan paw edema test.

Available for download on Saturday, June 29, 2019

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