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This special issue describes state-of-the-art statistical research in adaptive and sequential methods and the application of such methods in clinical trials. It provides 1 review article and 5 research articles contributed by some of the leading experts in this field. The review article gives a comprehensive overview of the outstanding methodology in the current literature that is related to adaptive and sequential clinical trials, while each of the 5 research articles addresses specific critical issues in contemporary clinical trials, as summarized below.


This editorial was originally published in the Journal of Probability and Statistics and is reposted here with the permission of the authors. Copyright © 2013 Yichuan Zhao, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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This work is licensed under a Creative Commons Attribution 3.0 License.

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