Date of Award

8-3-2008

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Mathematics and Statistics

First Advisor

Yu-sheng Hsu - Chair

Second Advisor

Mark Faupel

Third Advisor

Xu Zhang

Abstract

To significantly improve the early detection of cervical precancers and cancers, LightTouch™ is under development by SpectRx Inc.. LightTouch™ identifies cancers and precancers quickly by using a spectrometer to analyze light reflected from the cervix. Data from the spectrometer is then used to create an image of the cervix that highlights the location and severity of disease. Our research is conducted to find the appropriate models that can be used to generate map-like image showing disease tissue from normal and further diagnose the cervical cancerous conditions. Through large work of explanatory variable search and reduction, logistic regression and Partial Least Square Regression successfully applied to our modeling process. These models were validated by 60/40 cross validation and 10 folder cross validation. Further examination of model performance, such as AUC, sensitivity and specificity, threshold had been conducted.

Included in

Mathematics Commons

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