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Most children in kinship care with grandmothers in the U.S. have been abandoned or maltreated. The challenges these caregivers encounter often include poverty, social isolation, and diminished health. These factors may hinder the grandmother’s ability to provide a supportive family environment. The purpose of the present study was to determine levels of psychological distress in African American caregiving grandmothers and identify predictors of increased distress in African American custodial grandmothers. We hypothesized that diminished grandmother health, family resources and support, as well as increased child behavior problems, will predict psychological distress.