Date of Award
8-8-2017
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Donald Hamelberg
Second Advisor
Gregory Poon
Third Advisor
Maged Henary
Abstract
Among the peptidyl prolyl isomerases, the Cyclophilin family of proteins has been linked to various cellular activities such as regulation of homeostasis, mitochondrial permeability, and cell death. Their functionality spans throughout the cell and throughout all cell types as different isoforms. Previous studies done on Cyclophilin A revealed an interesting contact ensemble when bound to a substrate. Because of the similarity of CypA to its homologues, it is believed that they too will exhibit the same contact dynamics. We have defined the dynamics of cyclophilin isoforms through Molecular Dynamics simulations and determined their contact dynamics, characterizing their contact ensembles, and their relative dynamical conservation to each other.
DOI
https://doi.org/10.57709/10528055
Recommended Citation
Vu, Phuoc Jake D., "Determination of Dynamical Conservation in Human Cyclophilin Isoforms." Thesis, Georgia State University, 2017.
doi: https://doi.org/10.57709/10528055