Date of Award
8-8-2017
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Binghe Wang
Second Advisor
Dr. Donald Hamelberg
Third Advisor
Dr. Suri S. Iyer
Abstract
Hypoxia Inducible Factors (HIFs) are very important transcription factors that can respond to low oxygen concentrations in the cellular environment. Inhibition of HIF’s transcriptional activity represents a promising approach to new anticancer compounds. Herein, we describe the design and synthesis of a series of HIF-1 inhibitors. Evaluation of these inhibitors using a cell-based luciferase assay led to the discovery compounds with sub-micromolar potency.
DOI
https://doi.org/10.57709/10459923
Recommended Citation
Yang, Lingyun, "Design and Synthesis of Inhibitors of Hypoxia Inducible Factor-1-mediated Functions." Thesis, Georgia State University, 2017.
doi: https://doi.org/10.57709/10459923