Date of Award
12-18-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Maged Henary
Second Advisor
Dr. Alfons Baumstark
Third Advisor
Dr. Jerry Smith
Fourth Advisor
Dr. Gabor Patonay
Abstract
Near-infrared (NIR) fluorescence imaging has emerged as an attractive non-invasive approach for direct visualization of diseases which depends on the development of stable, highly specific and sensitive optical probes. The NIR region of the electronic spectrum offers a reduction in the background autofluorescence and an increase in the tissue penetration depth. Cyanine dyes have often been considered promising contrast optic agents owing to their photophysical properties.
Herein the synthesis of various penta- and heptamethine benzothiazole cyanine dyes has been described and their in vivo imaging efficacy was determined. Varying functionalities on the benzothiazole aromatic ring and changing substituents on the benzothiazolium nitrogen atom reflected subsequent changes in the imaging pattern and have resulted in the development of promising brain targeting agents.
DOI
https://doi.org/10.57709/3499738
Recommended Citation
Paranjpe, Shirish, "Synthesis of Novel Fluorescent Benzothiazole Cyanine Dyes as Potential Imaging Agents." Thesis, Georgia State University, 2012.
doi: https://doi.org/10.57709/3499738