Date of Award

8-11-2015

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Markus W. Germann

Second Advisor

W. David Wilson

Third Advisor

Maged Henary

Abstract

Structural and folding patterns of promoter regions (c-MYC, BCL) and telomeric (TTAGGG repeats) G-Quadruplexes were explored and their interactions with small molecules were tested. EAO-108 and MHI-21, symmetric heptamethine cyanines, were identified to exhibit strong interaction with the telomeric G-Quadruplex (mixed hybrid-1), while promoter region G-Quadruplexes were discriminated against. ZK-26 binds strongly to the c-MYC derivative and it is capable of discriminating between (3+1) hybrid-1 and -2 telomeric G-Quadruplexes with an initial binding preference towards the latter. To aid future binding studies, a novel labeling method is also described in this work.

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