Date of Award
7-13-2009
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Susanna F. Greer - Chair
Second Advisor
Richard Dix
Third Advisor
Zehava Eichenbaum
Abstract
The ubiquitin-proteasome pathway plays vital roles in multiple cellular processes including protein turnover and transcription regulation. The fate of a ubiquitinated protein is determined by the number of ubiquitin molecules added and the site to which they are added. Monoubiquitinated proteins are stabilized and often activated, while polyubiquitinated proteins are rapidly targeted for degradation. Major histocompatibility complex class II (MHC II) molecules are a vital part of the immune response and are responsible for presenting antigens to CD4+ T cells. The class II transactivator (CIITA) is the master regulator of MHC II transcription and has been shown to have increased transactivity when monoubiquitinated. The focus of this thesis is on the impact of ubiquitination on CIITA stability and MHC II gene expression through the identification of an E3 ligase that targets and ubiquitinates CIITA.
DOI
https://doi.org/10.57709/1059216
Recommended Citation
Brooks, Jeanne Kaye, "To Degrade or Not to Degrade: The Role of P300/CBP-Associated Factor (PCAF) in Ciita Stability and Ubiquitination." Thesis, Georgia State University, 2009.
doi: https://doi.org/10.57709/1059216