Date of Award
Fall 12-7-2011
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Casonya Matese Johnson
Second Advisor
Walter (Bill) William Walthall
Third Advisor
Parjit Kaur
Abstract
Notch signaling is important for development in Caenorhabditis elegans and the REF-1 family pro-teins, a set of the bHLH transcription factors, are the first targets of Notch signaling. Little is known about the molecular mechanisms employed by the REF-1 family to regulate development. In this project, I iden-tified novel targets of three REF-1 family proteins, HLH-25/HLH-28/HLH-29, and determined which target genes are activated and which are repressed by the REF-1 proteins. These targets were identified by gene expression microarray and were functionally categorized by Gene Oncology analysis. A systems biology approach was performed to identify networks associated with those targets. In addition to the mo-lecular genetics studies, I identified and better characterized the range of phenotypes induced by muta-tions in ref-1 family genes.
DOI
https://doi.org/10.57709/2391945
Recommended Citation
Wang, Kun, "Transcriptional Targets of the REF-1 Family Proteins: HLH-25/ HLH-28/HLH-29." Thesis, Georgia State University, 2011.
doi: https://doi.org/10.57709/2391945
Supplementary Tables S1234