Title
Neural Crosstalk Between Sympathetic Nervous System and Sensory Circuits to Brown Adipose Tissue
Date of Award
Spring 4-8-2013
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Dr. Timothy Bartness
Second Advisor
Dr. Aaron Roseberry
Third Advisor
Dr. Bingzhong Xue
Abstract
Brown adipose tissue (BAT) is a critical organ for non-shivering thermogenesis, which is under control of both sympathetic and sensory neural innervation. We utilized both a retrograde sympathetic nerve tract tracer pseudorabies virus and an anterograde sensory tract tracer the H129 strain of herpes simplex virus-1 to locate individual neurons across the neuroaxis that are part of the SNS outflow from brain to interscapular BAT and are part of the sensory input to the brain. We found specific neuronal phenotype of the double-infected neurons distributed from the hindbrain to the forebrain with highest densities in several discrete brain regions: the paraventricular hypothalamus (PVH), lateral hypothalamus (LHA), parabrachial nucleus (PB) and raphe pallidus (RPa). The neuroanatomical reality of the SNS-sensory feedback loops suggests coordinated control of BAT thermogenesis at several sites and indicates plasticity of SNS-sensory crosstalk.
DOI
https://doi.org/10.57709/4022136
Recommended Citation
Liu, Yang, "Neural Crosstalk Between Sympathetic Nervous System and Sensory Circuits to Brown Adipose Tissue." Thesis, Georgia State University, 2013.
doi: https://doi.org/10.57709/4022136