Date of Award
8-8-2017
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Desiree Wanders
Second Advisor
Huanbiao Mo
Third Advisor
Hang Shi
Abstract
Little is known about the ability of d-δ-tocotrienol to protect against obesity-induced inflammation. These studies were conducted to determine whether d-δ-tocotrienol inhibits highfat diet (HFD)-induced peripheral inflammation, and to explore potential mechanisms by which d-δ-tocotrienol affects inflammation. In two animal experiments, mice were fed a low-fat control diet, a high-fat control diet, or a HFD supplemented with d-δ-tocotrienol: 400 mg/kg diet (experiment #1) or 60 mg/kg body weight (experiment #2) for 14 weeks. Expression of inflammatory and anti-inflammatory markers was measured in liver and white adipose tissue, and phosphorylation of STAT3 was measured using western blot. d-δ-tocotrienol mitigate HFDinduced hepatic inflammation, despite having no effect on body weight, suggesting direct antiinflammatory effects of d-δ-tocotrienol independent of body weight loss. Mechanistic studies in 3T3-L1 adipocytes indicated that d-δ-tocotrienol suppresses LPS-induced inflammation through down-regulating STAT3 signaling. The potential for d-δ-tocotrienol as a treatment of obesity and related metabolic diseases requires further investigation.
DOI
https://doi.org/10.57709/10536943
Recommended Citation
Sharma, Shaligram, "Effects of D-Delta Tocotrienol on High-Fat Diet-Induced Peripheral Inflammation." Thesis, Georgia State University, 2017.
doi: https://doi.org/10.57709/10536943