Date of Award
5-2-2007
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Dr. Clancy N. Andrew - Chair
Second Advisor
Dr. Delon W. Barfuss
Third Advisor
Dr. Matthew S. Grober
Abstract
ABSTRACT Evidence from knockout studies in male mice and from experiments in male rats,in which expression of the estrogen receptor alpha (ERα) gene was inhibited in the medial preoptic area (MPO), suggests that ERα is important in the control of male rat mating behavior. Therefore, in this experiment, we tested the hypothesis that activation of ERα in the MPO is sufficient to maintain mating behavior in castrated male rats receiving subcutaneously (s.c.) dihydrotestosterone (DHT), a non-aromatizable androgen. Accordingly, castrated rats treated with DHT s.c. received MPO implants of either: (i) propyl-pyrazole-triol (PPT) (Stauffer, et al 2000; Katzenellenbogen, et al 2000), a selective ERα agonist, (ii) E2 (positive controls) or (iii) cholesterol (negative controls)and sexual behavior was monitored. PPT was as effective as E2 at maintaining mating behavior suggesting that, in the MPO, ERα is sufficient to mediate responses to E2 that underlie male rat mating behavior.
DOI
https://doi.org/10.57709/1059204
Recommended Citation
Habteab, Biniyam Seged, "Implant of a Selective Estrogen Receptor Alpha Agonist to the Male Rat Medial Preoptic Area Maintains Mating Behavior." Thesis, Georgia State University, 2007.
doi: https://doi.org/10.57709/1059204