Date of Award
12-14-2017
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Hao Xu
Abstract
This dissertation is concerned about four types of iron-catalyzed selective nitrogen atom transfer reactions developed in Xu group during 2012 and 2017, which can facilitate efficient access to valuable functional molecules from readily available petro-chemicals and other abundant starting olefinic materials. These iron-catalyzed stereoselective olefin difunctionalization processes include intermolecular olefin amino-oxygenation, amino-fluorination and trifluoromethyl azidation.
Compared to all other existing methods, our strategies have a broader substrate scope as well as improved or complementary selectivity in terms of regioslectivity, diastereoselectivity and enantioselectivity. To achieve a fine balance between catalyst reactivity, stability, and reaction selectivity, we explored a variety of iron catalysts, ligands and new amination reagents. Our methods allow chemists to conveniently transform a broad range of simple, abundant olefin precursors to a variety of functionalized vicinal amino alcohols and vicinal fluoro primary amines that are valuable in both organic synthesis and biomedical sciences.
DOI
https://doi.org/10.57709/11019658
Recommended Citation
Zhu, Chengliang, "Stereoselective Iron-catalyzed Intermolecular Olefin Amino-oxygenation, Amino-fluorination And Trifluoromethyl Azidation." Dissertation, Georgia State University, 2017.
doi: https://doi.org/10.57709/11019658