Ultrabright Fluorine Containing Squaraine Fluorophores Used for Biological Imaging

Author

Stefanie CasaFollow

Author ORCID Identifier

https://orcid.org/0000-0003-2948-2069

Date of Award

5-4-2022

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Maged Henary

Second Advisor

Jun Yin

Third Advisor

Samer Gozem

Abstract

This thesis outlines the relevance of fluorinated compounds in organic chemistry, more specifically in different scaffolds of fluorophores and the applications reported as well as highlighting the potential for different applications of the selected compounds in the first chapter. The second chapter describes the synthesis, characterization, optical, and physicochemical properties of a series of fluorinated squaraine dyes and highlights their potential in biological applications. The chemical structure of synthesized compounds was characterized using ¹H and ¹⁹F nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Biological distribution studies and further imaging studies were conducted following the full characterization of compounds.

DOI

https://doi.org/10.57709/28893595

Recommended Citation

Casa, Stefanie, "Ultrabright Fluorine Containing Squaraine Fluorophores Used for Biological Imaging." Thesis, Georgia State University, 2022.
doi: https://doi.org/10.57709/28893595

File Upload Confirmation

1