Date of Award
5-2024
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Giovanni Gadda
Second Advisor
Jenny Yang
Third Advisor
Ming Luo
Fourth Advisor
Kostiantyn Marichev
Abstract
Calcium is a universal messenger that regulates many biological and pathological processes by interacting with crucial calcium-binding proteins like the calcium-sensing receptor (CaSR). CaSR is a prominent protein that regulates various signaling pathways and diseases and detects changes in extracellular calcium concentration and metabolites to cause calcium changes in the intracellular environment. The study detailed in this thesis elucidates CaSR's presumed function in calcium homeostasis regulation and explores the binding and functional cooperativity of bacterially expressed CaSR using Trp-sensitized FRET assay. The second section of this thesis explores the optimization of TNCA a natural allosteric modulator of CaSR as our lead compound with the aid of structure-based drug design to develop novel CaSR therapeutics.
These investigations offer valuable insights into the molecular basis for CaSR-related diseases to facilitate the discovery of new therapeutics.
DOI
https://doi.org/10.57709/36484473
Recommended Citation
Ilupeju, Oluwadamilola Rosemary, "Exploring Calcium Sensing Mechanisms via the Calcium Sensing Receptor." Thesis, Georgia State University, 2024.
doi: https://doi.org/10.57709/36484473
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