Date of Award
4-21-2009
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Binghe Wang - Chair
Second Advisor
Zhen Huang
Third Advisor
Gangli Wang
Abstract
Fibrinogen aggregation is the last step in blood coagulation. Inhibition of fibrinogen aggregation could lead to anticoagulation effects. However, there is no good method for the ready evaluation of fibrinogen coagulation. A commonly used path method is slow and requires an expensive instrument. In this project, we have developed a microplate reader and In evaluating inhibitors of fibrinogen coagulations there is no good method. As an important process in hemostasis, fibrinogen coagulation is often detected by micro-plate reader. In our test of fibrinogen coagulation, we improved the observing and analyzing method by using photograph to see concentration-depended effect of thrombin inhibitors on the coagulation. Three known thrombin inhibitors, AEBSF, APMSF and PMSF, were applied to develop the method for detecting the fibrinogen coagulation. The results showed our method is of accuracy in determination of the amount of fibrin when compared with other types of methods.
DOI
https://doi.org/10.57709/1059240
Recommended Citation
Liu, Yidan, "A Novel Method for the Quantitative Evaluation of Fibrinogen Coagulation." Thesis, Georgia State University, 2009.
doi: https://doi.org/10.57709/1059240