Date of Award
4-22-2010
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Lucjan Strekowski - Committee Chair
Second Advisor
Dr. George Zheng - Committee Member
Third Advisor
Dr. Stuart Allison - Committee Member
Abstract
Of the seven existing classes of serotonin receptors, the 5-HT7 receptors (5-HT7Rs) are the most recently discovered. Abundance of 5-HT7 in the central nervous system is suggestive of the receptor’s role in several physiological and pathophysiological functions. Existing research has afforded a number of compounds exhibiting specific affinity to the receptor. These selective ligands can provide structural information about the receptor and can serve as the foundation for pharmacological profiling . This thesis describes the synthesis of substituted pyrimidines and pyridines for affinity to the 5-HT7 receptor. Organometallic species are the cornerstone for sev-eral of the synthetic pathways.
DOI
https://doi.org/10.57709/1331954
Recommended Citation
Blake, Ava L., "Synthesis of Substituted Pyrimidines and Pyridines as Ligands to the 5-HT7 Receptor." Thesis, Georgia State University, 2010.
doi: https://doi.org/10.57709/1331954