Date of Award
Summer 8-11-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Binghe Wang
Second Advisor
Dr. Stuart Allison
Third Advisor
Dr. Suri Iyer
Abstract
Cancer is one of the leading causes of death. There have been many investigations into therapeutic ways to prevent and reverse cancerous growth. We report a new approach in this thesis, which is to investigate the functions of Vitamin B1 (thiamine) in cancerous cells and their regulation. A number of thiamine analogs were synthesized to carry out the structure-activity relationship (SAR) studies with two transporters THTR1 and THTR2. Initial results show that the modifications of thiazole reduced the uptake of thiamine.
DOI
https://doi.org/10.57709/3098511
Recommended Citation
Dinh, Hieu T., "Design and Synthesis of Thiamine Analogs as Anti-Cancer Therapeutics." Thesis, Georgia State University, 2012.
doi: https://doi.org/10.57709/3098511