Date of Award
Fall 12-18-2013
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Peng George Wang
Abstract
Phenazines and heterocyclic N-oxides have proven to be interesting classes of antitumoral as well as antibiotic agents . The natural product myxin (1-hydroxy-6-methoxyphenazine- N5, N10-dioxide) which belongs to both of these unique classes of molecules, has been found to cause bio-reductively activated, radical-mediated DNA strand cleavage via a de-oxygenative mechanism, making it a potential anti-tumoral as well as anti-bactierial candidate. In order to investigate as well as improve the bioactive properties of myxin, the following study was designed to synthesize glycosylated myxin analogs. A small catalog of these compounds were synthesized, some of them exhibiting comparable biological activity to that of myxin.
DOI
https://doi.org/10.57709/4899796
Recommended Citation
Joyner, Jarin, "Synthesis of Novel Heterocyclic N-Oxide Glycosides: Glycosylation of Myxin Analogs." Thesis, Georgia State University, 2013.
doi: https://doi.org/10.57709/4899796