Date of Award
Fall 12-18-2013
Degree Type
Thesis
Degree Name
Master of Public Health (MPH)
Department
Public Health
First Advisor
Dr. Ike Okosun
Second Advisor
Dr. Kim Ramsey-White
Third Advisor
None
Fourth Advisor
None
Fifth Advisor
None
Sixth Advisor
None
Seventh Advisor
None
Abstract
ABSTRACT
Background: Evidence suggests that gestational diabetes mellitus (GDM) is associated with various metabolic conditions including elevated cholesterol, low HDL, elevated LDL, elevated triglycerides and obesity. However, comparative data on the association between GDM and various metabolic conditions across racial/ethnic groups are rare. This study focuses on differences in metabolic profiles among pregnant Non-Hispanic (NH) Whites, NH-Blacks, Mexican-Americans and women of other races/ethnicities with prediabetes and diabetes.
Method: Available data from the 1999 to 2010 survey waves of the National Health and Nutrition Examination Survey (NHANES) was used for this study. NHANES uses a stratified multistage probability sample of the civilian non-institutionalized population of the US chosen from a broad range of age groups and racial/ethnic backgrounds. Descriptive statistics were used to describe demographic variables, metabolic profiles across prediabetes/diabetes status. Univariate and multivariate logistic regression analyses were then used to determine the association between metabolic variables and prediabetes/diabetes across race/ethnicity.
Results: The study population (n=1417) consisted NH-Whites (N=620), NH-Blacks (N=219), Mexican-Americans (N=420), and “Other” races (N=168). Individuals with high LDL levels were significantly more likely to be diagnosed with GDM when compared to those with low LDL in both the crude (OR= 3.47, 95% CI= 1.90-6.33) and adjusted (OR= 2.81, 95% CI= 1.17-6.75) models. Individuals with high triglycerides levels were significantly more likely to be diagnosed with GDM when compared with individuals with low triglycerides in both the crude (OR= 2.44,95% CI= 1.36-4.38), and adjusted (OR= 1.30, 95% CI= 0.56-3.01) models. Individuals who are overweight/obese were significantly more likely to be diagnosed with GDM when compared with individuals normal weight both the crude (OR= 3.13, 95% CI= 1.28-7.64), and adjusted (OR= 2.44, 95% CI= 1.02-5.86) models. NH-Whites with elevated LDL and increased BMI are significantly more likely to be diagnosed with GDM; NH-Blacks with elevated triglycerides and increased BMI are significantly more likely to be diagnosed with GDM; Mexican-Americans with elevated triglycerides and increased BMI were significantly more likely to be diagnosed with GDM; Individuals of “Other” races with elevated LDL were significantly more likely to be diagnosed with GDM
Conclusion: With the exception of non-Hispanic Whites, pregnant American women with higher levels of cholesterols, high triglycerides, increased body mass index (25 kg/m2 or greater), and less than high school education were found to be at greater risks of diabetes. The result of this analysis suggests that healthcare professionals should be more aggressive in controlling these metabolic abnormalities in pregnant women. Early intervention prior to pregnancy may help delay the onset of prediabetes/diabetes. Empowerment of pregnant women in the management of their diabetes may also be critical in averting the detrimental effect of these metabolic abnormalities.
DOI
https://doi.org/10.57709/4934727
Recommended Citation
Henshaw, Nta E. MD, "Racial /Ethnic Differences Metabolic Profiles of American Women Diagnosed Diabetes Mellitus." Thesis, Georgia State University, 2013.
doi: https://doi.org/10.57709/4934727