Date of Award

8-8-2005

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Mathematics and Statistics

First Advisor

Susmita Datta - Chair

Second Advisor

Yichuan Zhao

Third Advisor

Gengsheng Qin

Abstract

Genetic factors have been shown to be involved in etiology of a poor response to the antidepressant treatment with sufficient dosage and duration. Our goal was to identify the role of polymorphisms in the poor response to the treatment. To this end, 5 functional polymorphisms in 109 patients diagnosed with unipolar, major depressive disorder are analyzed. Due to the small sample size, exact conditional tests are utilized to analyze the contingency table. The data analysis involves: (1) Exact test for conditional independence in a high dimensional contingency table; (2) Marginal independence test; (3) Exact test for three-way interactions. The efficiency of program always limits the application of exact test. The appropriate methods for enumerating exact tables are the key to improve the efficiency of programs. The algorithm of enumerating the exact tables is also introduced.

DOI

https://doi.org/10.57709/1059658

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