Title

Long Term Impact of Neonatal Injury in Male and Female Rats: Sex Differences, Mechanisms and Clinical Implications

Authors

Jamie L. LaPrairieFollow
Anne Z. Murphy PhD, Georgia State UniversityFollow

Document Type

Article

Publication Date

2010

Abstract

Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high‐technology intensive care over the last twenty years, ex‐preterm neonates may be exceedingly vulnerable to the long‐term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact.

Comments

This article was published in the journal Frontiers in Neuroendocrinology and is available to subscribers here: http://dx.doi.org/10.1016/j.yfrne.2010.02.001. Copyright © 2010 Elsevier Inc.

The post-print (post-peer-reviewed) version is posted here with permission of the author.

Recommended Citation

LaPrairie, J. L. & Murphy, A. Z. (2010). Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications. Frontiers in Neuroendocrinology, 31(2), 193–202. doi: 10.1016/j.yfrne.2010.02.001