Date of Award
Summer 6-8-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Nutrition
First Advisor
Murugi Ndirangu
Second Advisor
Allison Ross Eckard
Third Advisor
Anita Nucci
Abstract
Background: Few studies have evaluated habitual nutrient intake among HIV-infected youth in the United States, even though diet may influence disease progression and chronic complication risk.
Objective: This study determined micro- and macronutrient intake in HIV-infected youth, and investigated relationships among nutrient intake, demographics, lipid profiles, and HIV-related factors.
Design: HIV-infected subjects and healthy controls 1-25 years old were prospectively enrolled. Concomitant demographic, clinical and laboratory data were collected. Nutrient intake was assessed via 24-hr dietary recalls performed every 3 months for one year, analyzed with NDS-R software, and compared to Dietary Reference Intakes (DRIs) and Acceptable Macronutrient Distribution Ranges (AMDRs).
Results: Subjects with ≥2 food recalls were analyzed (175 HIV+; 43 controls). Groups were similar in age, race, sex, body mass index, and kilocalorie intake. Both groups did not meet DRI for several micronutrients. HIV+ subjects had lower %DRI than controls for vitamins A, E, pantothenic acid, magnesium, calcium, folate and potassium. Percent kilocalories from fat was above normal and higher in HIV+ patients. Caloric intake was negatively correlated with current and nadir CD4 counts. Zinc, riboflavin, and magnesium %DRI were positively associated with current CD4+ count. In HIV+ subjects not on antiretroviral therapy, HIV-1 RNA levels were negatively correlated with protein intake.
Conclusions: HIV+ youth have inadequate intake of several essential nutrients and poorer dietary intake compared to controls. Intake of some nutrients was associated with HIV-related factors. Further investigation is warranted to determine the impact of nutrition on HIV progression and chronic complication risk in this population.
Recommended Citation
Stricker, Lindsey A., "Suboptimal Nutrient Intake in HIV-Infected Youth and Associations with Serum Lipid Profiles and HIV-Related Factors." Thesis, Georgia State University, 2012.
https://scholarworks.gsu.edu/nutrition_theses/38