Date of Award
Spring 4-5-2012
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Physics and Astronomy
First Advisor
A. G. Unil Perera
Second Advisor
Mukesh Dhamala
Third Advisor
Brian Thoms
Fourth Advisor
Michael Crenshaw
Abstract
Regional tissue temperature dynamics in the brain are determined by the balance of the metabolic heat production rate and heat exchange with blood flowing through capillaries embedded in the brain tissue, the surrounding tissues and the environment. Local changes in blood flow and metabolism during functional activity can upset this balance and induce transient temperature changes. Invasive experimental studies in animal models have estab- lished that the brain temperature changes during functional activity are observable and a definitive relationship exists between temperature and brain activity. We present a theoreti- cal framework that links tissue temperature dynamics with hemodynamic activity allowing us to non-invasively estimate brain temperature changes from experimentally measured blood- oxygen level dependent (BOLD) signals. With this unified approach, we are able to pinpoint the mechanisms for hemodynamic activity-related temperature increases and decreases. In addition to these results, the potential uses and limitations of optical measurements are dis- cussed.
DOI
https://doi.org/10.57709/2757204
Recommended Citation
Rothmeier, Greggory H., "Brain Tissue Temperature Dynamics during Functional Activity and Possibilities for Optical Measurement Techniques." Thesis, Georgia State University, 2012.
doi: https://doi.org/10.57709/2757204