Date of Award
Master of Arts (MA)
Tricia Z. King, Ph.D.
Jeffrey G. Malins, Ph.D.
Jingyu Liu, Ph.D.
This study investigated fMRI Blood Oxygen Level-Dependent signal variability within individuals (within-individual neural variability; WINV) during a letter n-back task, and examined the relationship between WINV and cognitive abilities in healthy adults (N = 48). WINV in frontoparietal brain regions was modulated during vigilance and working memory (WM) trials of the n-back task, and was related to neuropsychological measures of vigilance and WM. WINV across the n-back task influenced n-back task performance; in this study, the inferior frontal junction exhibited a behavioral double dissociation between flexibility and stability at the region of interest level. A reading and language network was also queried to determine the influence of vigilance and WM on reading and language skills. As hypothesized, ROI and cluster-based variability in the n-back task was related to performance on assessments of WM, vigilance, reading, and language. Understanding WINV in these domains will inform research about WINV in clinical populations.
Steinberg, Stephanie, "Within-Individual Neural Variability in the N-Back Task: Relation to Neuropsychological Assessments of Executive Function, Reading, and Language." Thesis, Georgia State University, 2021.
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