Author ORCID Identifier

0000-0003-1095-3406

Date of Award

8-9-2022

Degree Type

Thesis

Degree Name

Master of Arts (MA)

Department

Psychology

First Advisor

Jessica A. Turner

Second Advisor

Gemma Modinos

Third Advisor

Tricia King

Abstract

Schizotypy is a set of personality traits that may predispose someone to develop a schizophrenia spectrum disorder. Social withdrawal is common in schizotypy and typically results in a lack of close relationships, little social support, and can exacerbate pre-existing psychiatric symptoms. White matter plays an integral role in cognition, yet it is still not understood which tracts influence social withdrawal. By collaborating with the ENIGMA Schizotypy working group, we gathered social withdrawal scores from the Community Assessment of Psychic Experiences and diffusion tensor imaging data from 375 participants. Using the ENIGMA DTI Pipeline, we were able to measure fractional anisotropy in six tracts and regress these numbers against social withdrawal scores. We studied the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, cingulum bundle, and the splenium of the corpus callosum. Through this analysis, we analyzed the relationship of white matter integrity and social withdrawal through the lens of schizotypy.

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