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Chemistry Dissertations

Dissertations from 2020 2020

MASS SPECTROMETRY BASED ANALYSIS OF PROTEIN N-GLYCOSYLATION IN BIOMARKER DISCOVERY AND GENE THERAPY WITH THE STUDY MODELS-HEMOPHILIA A INHIBITOR DEVELOPMENT AND rAAV, Arya Aloor

SYNTHESIS OF SELENIUM AND TELLURIUM MODIFIED NUCLEIC ACIDS FOR DNA CRYSTALLIZATION, STRUCTURE AND FUNCTION STUDIES, cen Chen

Characterization of self-regulatory mechanisms and internal dynamics of ETS transcription factor PU.1, Shingo Esaki

Student Understanding in Acid-Base Concepts in Chemistry: Conceptualization from General Chemistry II through Biochemistry, Nancy A. Kilpatrick

CHARACTERIZATION OF GLYCAN AND GLYCOPROTEIN BY MASS SPECTROMETRY FOR THERAPEUTIC DRUGS DEVELOPMETN AND BIOMARKER, Ding Liu

Chemoenzymatic synthesis of glycoconjugates and their applications, Shuaishuai Wang

Dissertations from 2019 2019

Spectroscopic Characterization and Bioanalytical Applications of Benzophenoxazine Derivatives and the Use of Dyes and Dye-Encapsulated Silica Nanoparticles for Fingerprint Detection, Eman Alsolmy

Design and Synthesis of Anticancer Agents by Targeting p53 Degradation and Photodynamic Therapy, Abiodun Anifowose

From Discovery to Implementation of Organic Chemistry Learning Models in Secondary and Post-Secondary Classrooms, Joy Ballard

Binding Modes and Near Infrared Photo Cleavage of DNA by Pentamethine Bridged Phenanthridinium and Quinolinium Carbocyanine Dyes, Kanchan Basnet

Synthesis and Characterization of Fluorescent Silica Nanoparticles with Large Stokes Shifts for Multiplexed Assays and Imaging, Gala M. Chapman

COMPREHENSIVE MASS SPECTROMETRY STUDIES FOR STRUCTURAL CHARACTERIZATION AND QUANTITATIVE DETERMINATION OF HETEROGENEOUS CARBOHYDRATE MOIETIES DERIVED FROM GLYCOPROTEINS FOR THERAPEUTIC PROTEIN DEVELOPMENT AND BIOMARKER DISCOVERY, Ebtesam Gashash

Footprint of Calcium on Regulation of Extracellular Calcium-Sensing Receptor and Connexin26, Rakshya Gorkhali

One-Pot Enzymatic Synthesis of UDP-GlcA and UDP-GalA and Chemoenzymatic Synthesis of a Library of Human Milk Oligosaccharides and Enzymatic Synthsis of O-antigen from P. aeruginosa serotype O11, Yuxi Guo

APPLICATIONS OF GLYCOCONJUGATES FOR ENZYME SUBSTRATE SPECIFICITY EXPLORATION, IMMUNE THERAPY, AND CARBOHYDRATE-PROTEIN INTERACTION STUDY, Shanshan Li

DNA-binding Small Molecules as Drug Agents that Interfere with Transcription Factors: the Development, the Potential and the Future, Beibei Liu

Monitoring Subcellular Calcium by Designed Calcium Sensors and the Calcium Sensing Receptor Structure and Function, Cassandra Miller

Development of Organic Carbon Monoxide prodrugs, Zhixiang Pan

Effects Of Different Halide Salts On DNA Photocleavage By 9-aminomethylanthracene Dyes, Mohammad Sadegh Safiarian

Spectroscopic and mechanistic investigation of two flavin-dependent enzymes: nitronate monooxygenase and choline oxidase, Dan Su

DEVELOPMENT OF CHEMOKINE RECEPTOR 4 TARGETED MRI CONTRAST AGENT FOR THE PRECISION MRI IMAGING OF CANCER AND METASTASIS, Shanshan Tan

From Macro to Micro: The Biophysical Importance of Nucleic Acids and Their Interactive Partners, Tam Vo

FULLY AUTOMATED ENZYMATIC SYNTHESIS OF GLYCANS, Jiabin Zhang

Profiling Ubiquitin Chain Specificity and Topology Using Di-ubiquitin Probes, Han Zhou

Mass Spectrometry-based Glycoprotein Characterization, He Zhu

Dissertations from 2018 2018

Mechanistic Studies on D-arginine Dehydrogenase and Functional Annotation of a Novel NADH:quinone Oxidoreductase (PA1024), Jacob A. Ball

Modeling And Experiments Of Electroosmotic Flow Effects On The Ion Transport In Nanopipettes, Warren D. Brown

Insights into the Association of Proteins and Small Molecules with the Minor Groove of DNA, Emma Kathleen Carter

Synthetic Glycans Analogues for the Precise Point-of-care Detection of Pathogens, Xikai Cui

Design and development of small molecule based biosensors for detection of pathogens, Amrita Das

Structure, Function and Potential Application Studies of Selenium Substituted Nucleic Acids, Ziyuan Fang

Structure-Function Relationships of the Nucleocapsid in Vesicular Stomatitis Virus, Ryan Gumpper

Understanding the Recognition of Mixed Sequence DNA through Minor Groove Binding Compounds, Narinder Kaur Harika

SMALL MOLECULE INHIBITORS OF G9a AND HDAC FOR TARGETED CANCER THERAPY AND DNA ENCODED GLYCAN LIBRARY (DEGL) FOR EARLY DETECTION OF CANCER, Shukkoor Muhammed kondengaden

Characterizing the Optical and Electrochemical Properties of Monolayer-Protected Noble Metal Nanoclusters, Jonathan W. Padelford

Late Quaternary East African Environmental Change based on Mineralogical and Geochemical Analysis of Outcrop and Core Material from the Southern Kenya Rift, Nathan Rabideaux

Integrating Protein Dynamics And Enhanced Conformational Ensembles To Better Understand Their Role In Biomolecular Function, Isela Rodriguez-Bussey

Development of Novel Collagen-targeted Protein-based MRI Contrast Agent for Imaging of Chronic Liver and Heart Diseases, Mani Salarian

Design and Development of Prodrugs of Sulfur Dioxide and Design and Synthesis of Prodrugs of Thiamine Monophosphate Mimics as Pyruvate Dehydrogenase Kinase Inhibitors, Wenyi Wang

Enzymatic Synthesis of Common Sugar Nucleotide and Therapeutic Oligosaccharides, Cong Xiao

Developing Chemical Tools for Probing Biological Problems: From Prodrugs of Various Sulfur Species to Bacterial Sensitizers for Combination-Therapy, Bingchen Yu

APPROACHES TO CONSTRUCT GLYCAN LIBRARY & STRUCTURE BASED DESIGN, SYNTHESIS AND ACTIVITY STUDIES OF SMALL HYBRID MOLECULES AS HDAC AND G9A DUAL INHIBITORS, Qing Zhang

Glycosylation: Function, Synthesis and Application, Hailiang Zhu

Dissertations from 2017 2017

USING DIFFERENT ANALYTICAL TECHNIQUES AND SYNTHETICALLY TAILORED SILICA NANOPARTICLES IN DRUG SEPARATIONS AND HYDROPHOBICITY-BASED DETECTION APPLICATIONS, Walid Abdelwahab

Assessing Organic Chemistry Students’ Understanding Of Chemical Bonding Concepts and their Perception of a Project-based Lab, Nikita L. Burrows

Heme Iron Catalysis: Contrast to Non-Heme Iron Enzymes, Kednerlin Dornevil

Characterization of Nucleic Acids and Nucleic Acid Binding Proteins Using NMR, Marina Evich

Synthesis, Development, and Exploration of Two Small Molecule Scaffolds Toward Discovery of Novel and Potent Inhibitors of the Hypoxia-Inducible Factor-1 Pathway, Jalisa H. Ferguson

DESIGN, SYNTHESIS AND ANALYSIS OF SMALL MOLECULE HETEROCYCLIC AROMATIC-BASED CXCR4 MODULATORS, Theresa D. Gaines

COMPUTATIONAL INVESTIGATIONS OF BIOMOLECULAR MOTIONS AND INTERACTIONS IN GENOMIC MAINTENANCE AND REGULATION, Bradley R. Kossmann

Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging, Andrew R. Levitz

Comprehensive Glycoproteomics and Glycomics Study of N-Linked Glycans and N-Glycoproteins, Xu Li

Applications of Monolithic Capillary Electrochromatography (CEC): Method Development and Quantitation of Metabolites in Prostate Tissue and Insights into Chiral Recognition Mechanism, Yang Lu

Design Of Genetically-Encoded Ca2+ Probes With Rapid Kinetics For Subcellular Application, Florence Reddish

Biochemical and Biophysical Studies of Heme Transport Proteins: HtaA, HtaB, and ChtB from the Corynebacterium diphtheriae, Rizvan C. Uluisik

Facile Enzymatic Synthesis of Ketoses and Chemoenzymatic Reporter Strategy for Probing Complex Glycans, liuqing Wen

Understanding Function of Carbohydrates by Synthesis of Structurally-defined Glycopeptides/Glycoproteins and Glycans, Zhigang Wu

New Chemical Strategies for prodrug preparations: from sulfide to doxorubicin, Yueqin Zheng

Stereoselective Iron-catalyzed Intermolecular Olefin Amino-oxygenation, Amino-fluorination And Trifluoromethyl Azidation, Chengliang Zhu

Dissertations from 2016 2016

Application of Human Glycosyltransferases in N-glycan Synthesis and Their Substrate Specificity Studies, Angie Dayan Calderon Molina

Biochemical and Biophysical Studies of Heme Binding Proteins from the Corynebacterium diphtheriae and Streptococcus pyogenes Heme Uptake Pathways, Elizabeth B. Draganova

Novel Anticancer Agents That Upregulate p53 and A New Type of Neighbouring Group Assisted Click Reactions, Alexander B. Draganov

To Affinity & Beyond: Exploring Sequence Selectivity of Small Molecules for the DNA Minor Groove, Sarah Laughlin-Toth

Chiral capillary electrophoresis-mass spectrometry: developments and applications of novel glucopyranosdie molecular micelles, yijin liu

Transforming Dihydroxyacetone Phosphate-Dependent Aldolases Mediated Aldol Reactions From Flask Reaction Into Cell-Based Synthesis & Studying The Mechanism Of Chemical Desialylation In The Life Processes, Mohui Wei

Chemical and Chemoenzymatic Synthesis of Outer Core Oligosaccharide of Escherichia Coli R3 and a Library of Human Milk Oligosaccharides & Design and Synthesis of Glycoconjugates, Zhongying Xiao

Iron Catalyzed Selective Nitrogen Atom Transfer Reactions for Olefin Difunctionalization: Iron Catalyzed Direct Diazidation and Asymmetric Intramolecular Aminohydroxylation of Olefin, Yongan Yuan

CALCIUM REGULATION OF CELL-CELL COMMUNICATION AND EXTRACELLULAR SIGNALING, Juan Zou

Dissertations from 2015 2015

Synthesis of Small Molecules for Diagnostics and Therapeutics of Influenza Virus, Hieu T. Dinh

Calcium-Sensing Receptor Mediated Calcium Signaling in Cancer Bone Metastasis, Jie Feng

Mass Transport through Conical Nanopipettes and its Applications in Energy Conversion and Crystallization, Yan Li

I. Kinetic and Computational Modeling Studies of Dimethyldioxirane Epoxidations II. Adressing Misconceptions About Energy Changes in Chemical Reactions Through Hands-on Activities, Davita McTush-Camp

Synthetically Tailored Cyanines for Imaging and Therapy, Eric Owens

Kinetic and Structural Studies on Flavin-dependent Enzymes involved in Glycine Betaine Biosynthesis and Propionate 3-nitronate Detoxification, Francesca Salvi

Biochemical and Mechanistic Studies of Nitronate Monooxygenase and Roles of Histidine Residues in Select Flavoprotein Oxidases, Crystal L. Smitherman

Computational Perspective on Intricacies of Interactions, Enzyme Dynamics and Solvent Effects in the Catalytic Action of Cyclophilin A, Safieh Tork Ladani

Quantification of Nonlinear And Dynamic Charge Transport Through Nanoscale Confinements, Dengchao Wang

Studies on Boronic Acid-modified Nucleotides for Diagnostic Applications and Development of Fluorescent Chemoprobes for Molecules of Biological Importance, Ke Wang

Development of Glycan Based Diagnostics to Detect Pathogens, xiaohu Zhang

Dissertations from 2014 2014

The Spectrochemical Characterization of Novel Vis-NIR Fluorescence Dyes and Developing a Laser Induced Fluorescence Capillary Zone Electrophoresis (LIF-CZE) Technique to Study Alkanesulfonate Monooxygenase, Garfield Beckford

Mechanistic Enzymology of Flavin-dependent Catalysis in Bacterial D-Arginine Dehydrogenase and Choline Oxidase, Swathi Gannavaram

Heme-dependent Tryptophan Oxidation: Mechanistic Studies on Tryptophan 2,3-Dioxygenase and MauG, Jiafeng Geng

Synthesis of Aza-Heterocyclic Monoamidines as Potential DNA Minor Groove Binders, Anti-Trypanosomals, and Boron Neutron Capture Therapy Agents, Julius Green

Detection and inhibition of influenza using synthetic sialosidesc, Yun He

Structural and Mechanistic Studies on α-Amino β-Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase, Lu Huo

Novel Selenium-modified Nucleic Acids For Structural and Functional Studies, Sibo Jiang

Using Molecular Dynamics to Elucidate the Mechanism of Cyclophilin, Lauren McGowan

Development of Novel Protein-Based MRI Contrast Agents for the Molecular Imaging of Cancer Biomarkers, Fan Pu

Atom-Specific Modification of Uracil Bases with Selenium for RNA Structure and Function Studies, Huiyan Sun

Molecular Dynamics Simulations Towards The Understanding of the Cis-Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes, Hector Velazquez

From "Click" to "Click and Release", Using Inverse Electron Demand Diels-Alder Reaction for Chemical and Medicinal Applications, Danzhu Wang

One DNA minor groove, many possibilities: from sequence recognition to transcription factor inhibition, Shuo Wang

Cleavage of Lipids and DNA by Metal Ions and Complexes, Dominique Williams

“Coarse Grained" Bead Modeling of Macromolecules Transport in Free Solution and in a Gel, Hengfu Wu

Modeling Assemblies and Interactions at the Replication Fork: Sliding Clamps and Clamp Interacting Enzymes, Xiaojun Xu

Integration Of Extracellular And Intracellular Signals Via The Calcium Sensing Receptor (CASR), Chen Zhang

Dissertations from 2013 2013

Design and Synthesis of HIF-1 Inhibitors as Anti-cancer Therapeutics, Sarah Burroughs

Inhibitors of SecA as Potential Antimicrobial Agents, Arpana S. Chaudhary

The Structure and Function Study of Three Metalloenzymes That Utilize Three Histidines as Metal Ligands, Yan Chen

Development of RNA Microchip for Pathogen and Cancer Direct Detection, Lilian W. Kamau-Gatogo

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