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Dissertations from 2024

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Carbon Monoxide Donors: From Synthetic Applications to Reassessment of Commercially Available Compounds, Nicola Bauer

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Design and Evaluation of Novel Delivery Approaches for Small Molecule Drugs, Mohammed Shameer Kondengadan

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Uncovering the Mechanisms of Allosteric Interactions in Proteins: A Comprehensive Analysis Using Molecular Dynamics, Network Analysis, and Energy Calculations, Jacques Kumutima

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Development of a Collagen-targeted Protein-based Contrast Agent for Molecular MR Imaging of Lung Fibrosis, Cancer, and Metastasis, Dongjun Li

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Synthesis and Evaluation of Cereblon-Recruiting HaloPROTACs, Britton Ody

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Development of Point-Of-Care Assay to Monitor Intestinal Bowel Disease Biomarkers, Xiaolin Sheng

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Molecular Mechanism of Calcium Sensing Receptor Mediated Calcium Signaling, Li Tian

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Prodrug Strategies for Drug Delivery: from Carbon Monoxide to PROTACs, Ce Yang

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Molecular Modeling of the Complex Protein Machinery of Nucleotide Excision Repair, Jina Yu

Dissertations from 2023

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Dissecting Ubiquitin Chain Editing Mechanisms of Deubiquitinating Enzymes Enabled by Linkage-Specific di-Ubiquitin Probes, Tomaya Carpenter

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Preclinical Applications of Targeted Protein-Based Contrast Agents for Molecular MRI Imaging, Zongxiang Gui

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Development of Point-Of-Care Assays to Detect Biologically Relevant Analytes, Tianwei Jia

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Quantum Chemical and QM/MM Calculations on Flavin and Flavin-Binding Fluorescent Proteins, Mohammad Pabel Kabir

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Analyzing Undergraduate Problem Solving in Proton NMR: A Comprehensive Examination and Assessment Tool for Conceptual Understanding, Sujani Kariyawasam Gamage

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Blackberry Consumption Protects Against E-Cigarette-Induced Vascular Oxidative Stress, Maureen Meister

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Raspberry Polyphenols Target Molecular Pathways of Heart Failure, Rami Najjar

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Rational Design and Synthesis of NIR Dyes for Biomedical Imaging, Md Shamim

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Leveraging Chemical Tools for Improving Therapeutic Delivery of Carbon Monoxide and Potency of Anthraquinone-based MDM2 Inhibitors, Ravi Tripathi

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Unraveling the Mechanism Behind the Phototoxicity of Polycyclic Aromatic Dyes, Aikohi Ugboya

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Nanotransport Enabled Single-Entity Method for Actively Controlled Nucleation and High-Quality Crystal Synthesis, Ruoyu Yang

Dissertations from 2022

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Covalently Bonded Capillary Columns and Glycopeptide-Based Molecular Micelles for Enantioseparation in Micellar Electrokinetic Chromatography Coupled to Mass Spectrometry, Ferdoushi Akter

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Rational Design Of Small Bioprobes For Biomedical Applications, Emmanuel Ramsey Buabeng

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Applications of Capillary Electrochromatography-mass spectrometry: Method Development and validation of Kynurenine Pathway Metabolites Analyses in Human Plasma and Characterization of Hydrophilic Interactions with Performance Evaluation in CEC Based Monolithic Stationary Phases, A S M Mojibur Rahaman Chawdhury

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Revealing Plasmonic Coupling of Gold Nanoparticles on a Mirror Using Spectromicroscopy, Seth Filbrun

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Chemical Biology Tools for Probing Protein Glycosylation and Ubiquitination Pathways, Xuan Fu

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The Importance of Fitting In: Investigating the Role of Protein Dynamics in DNA Sequence Specificity, Kenneth Huang

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Profiling Substrates of HECT and RBR Type E3 Ligases by Orthogonal Ubiquitin Transfer Cascade, Ruochuan Liu

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Near Infrared Electrogenerated Chemiluminescence and Related Electrochemical Properties of Gold Nanoclusters, Hedi Ma

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Single Molecule Fluorescence Imaging of Nanoconfinement in Porous Materials, Nourhan Mansour

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The Application of X-ray Crystallography for Structural Information on DNA-Amidine Complexes and Detailed Examination of Minor Groove Structures of B-DNA, Edwin Ogbonna

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Open Tubular Capillary Electrochromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry for Targeted Metabolomics, Vijay Patel

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Biochemical Characterization of Selected Flavin-Dependent Metabolic Enzymes of Pseudomonas aeruginosa PAO1 Toward Alternative Therapeutic Development, Joanna Quaye

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Water Use Patterns of a Riparian Forest in a Humid Subtropical Catchment in the Southeastern United States, Jeffrey Riley

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Defining and Describing the Complex Nature of Undergraduates’ Chemistry-Specific Mindset Beliefs, Deborah L. Santos

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Probing the Regulatory Role of Allostery via Protein Dynamics of Biological Systems, Michael G. Souffrant

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A New Ferrihydrite-Multiwalled Carbon Nanotubes Hybrid Composite for Removing Aqueous Contaminants by Electrosorption: A Case Study of PFOA Remediation, Thien Tran

Dissertations from 2021

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Characterization of the Contributions of Hydration in Protein-DNA Specificity via Structurally Conserved ETS Family Transcription Factors PU.1 and Ets-1, Amanda V. Albrecht

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Chemistry of a Dehydrogenase and Di-heme Enzyme Related to Tryptophan Oxidation, Christopher Ian Davis

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Integration of Calcium Signaling by Dynamically Tuned Calcium Indicators and Calcium Sensing Receptor, Xiaonan Deng

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Glycopeptide Preparation and Application for Alzheimer?s Diagnostics and Influenza Immunization, Christopher Gibbons

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Characterizing Novel Filovirus Proteins and 3-Deazaneplanocin A Derivatives as Antivirals against Non-Segmented Negative Sense RNA Viruses, Joyce Sweeney Gibbons

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Methods for Dynamical Analysis of Biomolecular Mechanisms in Molecular Dynamics Simulations, Ka Chun Ho

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Development and Optimization of a Human Collagen-Targeted Protein-based MRI Contrast Agent for Early Detection of Chronic Human Diseases, Oluwatosin Ibhagui

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Structural and Mechanistic Investigation of D-Arginine Dehydrogenase and L-Arginine Dehydrogenase from Pseudomonas Aeruginosa, Archana Iyer

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A reporter platform for characterizing transcription factor-DNA interactions in live cells, Hye Mi Kim

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Kinetic Studies and Investigation of Active Site Loop Dynamics in a Flavin-Dependent Enzyme, D-Arginine Dehydrogenase, Daniel Ouedraogo

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Improving Potency of Existing Drugs: From Developing Bacterial Sensitizers for Existing Antimicrobials Towards Multi-Drug Resistant Strains to Targeting Cancer Drugs to the Mitochondria, Manjusha Roy Choudhury

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Structure And Function Of Viral RNA-Host Protein Interactions Among Flaviviruses, Jessica Siemer

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The CD98 is a Potential Target for Non-Alcoholic Fatty Liver Disease Treatments, Heliang Song

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Utilizing Molecular Probes to Examine Protein Structure-Function Relationships, James Terrell

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Profiling Substrate Proteins of Ring and RBR type E3 ligases by Orthogonal Ubiquitin Transfer and the Development of a Peptide Activator Targeting HECT-type E3 ligase, Li Zhou

Dissertations from 2020

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Mass Spectrometry Based Analysis of Protein N-Glycosylation in Biomarker Discovery and Gene Therapy with the Study Models-Hemophilia A Inhibitor Development and rAAV, Arya Aloor

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Non-Alcoholic Fatty Liver and Hepatocarcimona Attenuation by Specific CD98 Down-Regulation Via Nanovectors, Brandon S. Canup

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Synthesis of Selenium and Tellurium Modified Nucleic Acids For DNA Crystallization, Structure and Function Studies, cen Chen

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Caging Carbon Monoxide For Therapeutic Applications And Carbonylation Reactions, Ladie Kimberly C. De La Cruz

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Computational Investigations of Biomolecular Mechanisms in Genomic Replication, Repair and Transcription, Thomas Dodd

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Characterization of self-regulatory mechanisms and internal dynamics of ETS transcription factor PU.1, Shingo Esaki

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Student Understanding in Acid-Base Concepts in Chemistry: Conceptualization from General Chemistry II through Biochemistry, Nancy A. Kilpatrick

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Development of Point-of-Care Assays for Different Biologically Relevant Analytes, Dandan Liu

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Characterization of Glycan and Glycoprotein by Mass Spectrometry for Therapeutic Drugs Development and Biomarker, Ding Liu

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Regulation Of Cardiovascular Homeostasis By Autophagy, Jing Mu

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Unveiling the Polymerase Complex of Negative Stranded RNA Viruses, Chelsea Severin

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Chemoenzymatic synthesis of glycoconjugates and their applications, Shuaishuai Wang

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What Controls the Controller: Structure and Function Characterizations of Transcription Factor PU.1 Uncover Its Regulatory Mechanism, Suela Xhani Georgia State University

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Development of esterase-sensitive persulfide prodrugs and studies of CO-independent reactivities from ruthenium-based CO-releasing molecules, Zhengnan Yuan

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Development of Multiscale Spectro-microscopic Imaging System and Its Applications, Fei Zhao

Dissertations from 2019

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Spectroscopic Characterization and Bioanalytical Applications of Benzophenoxazine Derivatives and the Use of Dyes and Dye-Encapsulated Silica Nanoparticles for Fingerprint Detection, Eman Alsolmy

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Design and Synthesis of Anticancer Agents by Targeting p53 Degradation and Photodynamic Therapy, Abiodun Anifowose

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From Discovery to Implementation of Organic Chemistry Learning Models in Secondary and Post-Secondary Classrooms, Joy Ballard

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Binding Modes and Near Infrared Photo Cleavage of DNA by Pentamethine Bridged Phenanthridinium and Quinolinium Carbocyanine Dyes, Kanchan Basnet

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Synthesis and Characterization of Fluorescent Silica Nanoparticles with Large Stokes Shifts for Multiplexed Assays and Imaging, Gala M. Chapman

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Comprehensive Mass Spectrometry Studies for Structural Characterization and Quantitative Determination of Heterogeneous Carbohydrate Moieties Derived from Glycoproteins for Therapeutic Protein Development and Biomarker Discovery, Ebtesam Gashash

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Footprint of Calcium on Regulation of Extracellular Calcium-Sensing Receptor and Connexin26, Rakshya Gorkhali

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One-Pot Enzymatic Synthesis of UDP-GlcA and UDP-GalA and Chemoenzymatic Synthesis of a Library of Human Milk Oligosaccharides and Enzymatic Synthsis of O-antigen from P. aeruginosa serotype O11, Yuxi Guo

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Applications of Glycoconjugates for Enzyme Substrate Specificity Exploration, Immune Therapy, and Carbohydrate-Protein Interaction Study, Shanshan Li

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DNA-binding Small Molecules as Drug Agents that Interfere with Transcription Factors: the Development, the Potential and the Future, Beibei Liu

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Monitoring Subcellular Calcium by Designed Calcium Sensors and the Calcium Sensing Receptor Structure and Function, Cassandra Miller

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Development of Organic Carbon Monoxide prodrugs, Zhixiang Pan

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Effects Of Different Halide Salts On DNA Photocleavage By 9-aminomethylanthracene Dyes, Mohammad Sadegh Safiarian

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Spectroscopic and mechanistic investigation of two flavin-dependent enzymes: nitronate monooxygenase and choline oxidase, Dan Su

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Development of Chemokine Receptor 4 Targeted MRI Contrast Agent for the Precision MRI Imaging of Cancer and Metastasis, Shanshan Tan

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From Macro to Micro: The Biophysical Importance of Nucleic Acids and Their Interactive Partners, Tam Vo

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Fully Automated Enzymatic Synthesis of Glycans, Jiabin Zhang

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Profiling Ubiquitin Chain Specificity and Topology Using Di-ubiquitin Probes, Han Zhou

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Mass Spectrometry-based Glycoprotein Characterization, He Zhu

Dissertations from 2018

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Mechanistic Studies on D-arginine Dehydrogenase and Functional Annotation of a Novel NADH:quinone Oxidoreductase (PA1024), Jacob A. Ball

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Modeling And Experiments Of Electroosmotic Flow Effects On The Ion Transport In Nanopipettes, Warren D. Brown

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Insights into the Association of Proteins and Small Molecules with the Minor Groove of DNA, Emma Kathleen Carter

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Synthetic Glycans Analogues for the Precise Point-of-care Detection of Pathogens, Xikai Cui

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Design and development of small molecule based biosensors for detection of pathogens, Amrita Das

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Structure, Function and Potential Application Studies of Selenium Substituted Nucleic Acids, Ziyuan Fang

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Structure-Function Relationships of the Nucleocapsid in Vesicular Stomatitis Virus, Ryan Gumpper

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Understanding the Recognition of Mixed Sequence DNA through Minor Groove Binding Compounds, Narinder Kaur Harika

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Small Molecule Inhibitors of G9A And HDAC for Targeted Cancer Therapy and DNA Encoded Glycan Library (DEGL) For Early Detection of Cancer, Shukkoor Muhammed kondengaden

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Characterizing the Optical and Electrochemical Properties of Monolayer-Protected Noble Metal Nanoclusters, Jonathan W. Padelford

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Late Quaternary East African Environmental Change based on Mineralogical and Geochemical Analysis of Outcrop and Core Material from the Southern Kenya Rift, Nathan Rabideaux

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Integrating Protein Dynamics And Enhanced Conformational Ensembles To Better Understand Their Role In Biomolecular Function, Isela Rodriguez-Bussey

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Development of Novel Collagen-targeted Protein-based MRI Contrast Agent for Imaging of Chronic Liver and Heart Diseases, Mani Salarian

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Design and Development of Prodrugs of Sulfur Dioxide and Design and Synthesis of Prodrugs of Thiamine Monophosphate Mimics as Pyruvate Dehydrogenase Kinase Inhibitors, Wenyi Wang

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Enzymatic Synthesis of Common Sugar Nucleotide and Therapeutic Oligosaccharides, Cong Xiao