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Chemistry Dissertations

Dissertations from 2018 2018

Developing Chemical Tools for Probing Biological Problems: From Prodrugs of Various Sulfur Species to Bacterial Sensitizers for Combination-Therapy, Bingchen Yu

Approaches to Construct Glycan Library & Structure Based Design, Synthesis and Activity Studies of Small Hybrid Molecules as HDAC and G9A Dual Inhibitors, Qing Zhang

Glycosylation: Function, Synthesis and Application, Hailiang Zhu

Dissertations from 2017 2017

Using Different Analytical Techniques and Synthetically Tailored Silica Nanoparticles in Drug Separations and Hydrophobicity-Based Detection Applications, Walid Abdelwahab

Assessing Organic Chemistry Students? Understanding Of Chemical Bonding Concepts and their Perception of a Project-based Lab, Nikita L. Burrows

Heme Iron Catalysis: Contrast to Non-Heme Iron Enzymes, Kednerlin Dornevil

Characterization of Nucleic Acids and Nucleic Acid Binding Proteins Using NMR, Marina Evich

Synthesis, Development, and Exploration of Two Small Molecule Scaffolds Toward Discovery of Novel and Potent Inhibitors of the Hypoxia-Inducible Factor-1 Pathway, Jalisa H. Ferguson

Design, Synthesis and Analysis of Small Molecule Heterocyclic Aromatic-Based CXCR4 Modulators, Theresa D. Gaines

Computational Investigations of Biomolecular Motions and Interactions in Genomic Maintenance and Regulation, Bradley R. Kossmann

Synthesis of Various Classes of Cyanine Fluorophores and Their Application In In Vivo Tissue Imaging, Andrew R. Levitz

Comprehensive Glycoproteomics and Glycomics Study of N-Linked Glycans and N-Glycoproteins, Xu Li

Applications of Monolithic Capillary Electrochromatography (CEC): Method Development and Quantitation of Metabolites in Prostate Tissue and Insights into Chiral Recognition Mechanism, Yang Lu

Design Of Genetically-Encoded Ca2+ Probes With Rapid Kinetics For Subcellular Application, Florence Reddish

Biochemical and Biophysical Studies of Heme Transport Proteins: HtaA, HtaB, and ChtB from the Corynebacterium diphtheriae, Rizvan C. Uluisik

Facile Enzymatic Synthesis of Ketoses and Chemoenzymatic Reporter Strategy for Probing Complex Glycans, liuqing Wen

Understanding Function of Carbohydrates by Synthesis of Structurally-defined Glycopeptides/Glycoproteins and Glycans, Zhigang Wu

New Chemical Strategies for prodrug preparations: from sulfide to doxorubicin, Yueqin Zheng

Stereoselective Iron-catalyzed Intermolecular Olefin Amino-oxygenation, Amino-fluorination And Trifluoromethyl Azidation, Chengliang Zhu

Dissertations from 2016 2016

Application of Human Glycosyltransferases in N-glycan Synthesis and Their Substrate Specificity Studies, Angie Dayan Calderon Molina

Biochemical and Biophysical Studies of Heme Binding Proteins from the Corynebacterium diphtheriae and Streptococcus pyogenes Heme Uptake Pathways, Elizabeth B. Draganova

Novel Anticancer Agents That Upregulate p53 and A New Type of Neighbouring Group Assisted Click Reactions, Alexander B. Draganov

To Affinity & Beyond: Exploring Sequence Selectivity of Small Molecules for the DNA Minor Groove, Sarah Laughlin-Toth

Chiral capillary electrophoresis-mass spectrometry: developments and applications of novel glucopyranosdie molecular micelles, yijin liu

Transforming Dihydroxyacetone Phosphate-Dependent Aldolases Mediated Aldol Reactions From Flask Reaction Into Cell-Based Synthesis & Studying The Mechanism Of Chemical Desialylation In The Life Processes, Mohui Wei

Chemical and Chemoenzymatic Synthesis of Outer Core Oligosaccharide of Escherichia Coli R3 and a Library of Human Milk Oligosaccharides & Design and Synthesis of Glycoconjugates, Zhongying Xiao

Iron Catalyzed Selective Nitrogen Atom Transfer Reactions for Olefin Difunctionalization: Iron Catalyzed Direct Diazidation and Asymmetric Intramolecular Aminohydroxylation of Olefin, Yongan Yuan

Calcium Regulation of Cell-Cell Communication and Extracellular Signaling, Juan Zou

Dissertations from 2015 2015

Synthesis of Small Molecules for Diagnostics and Therapeutics of Influenza Virus, Hieu T. Dinh

Calcium-Sensing Receptor Mediated Calcium Signaling in Cancer Bone Metastasis, Jie Feng

Mass Transport through Conical Nanopipettes and its Applications in Energy Conversion and Crystallization, Yan Li

I. Kinetic and Computational Modeling Studies of Dimethyldioxirane Epoxidations II. Adressing Misconceptions About Energy Changes in Chemical Reactions Through Hands-on Activities, Davita McTush-Camp

Synthetically Tailored Cyanines for Imaging and Therapy, Eric Owens

Kinetic and Structural Studies on Flavin-dependent Enzymes involved in Glycine Betaine Biosynthesis and Propionate 3-nitronate Detoxification, Francesca Salvi

Biochemical and Mechanistic Studies of Nitronate Monooxygenase and Roles of Histidine Residues in Select Flavoprotein Oxidases, Crystal L. Smitherman

Computational Perspective on Intricacies of Interactions, Enzyme Dynamics and Solvent Effects in the Catalytic Action of Cyclophilin A, Safieh Tork Ladani

Quantification of Nonlinear And Dynamic Charge Transport Through Nanoscale Confinements, Dengchao Wang

Studies on Boronic Acid-modified Nucleotides for Diagnostic Applications and Development of Fluorescent Chemoprobes for Molecules of Biological Importance, Ke Wang

Development of Glycan Based Diagnostics to Detect Pathogens, xiaohu Zhang

Dissertations from 2014 2014

The Spectrochemical Characterization of Novel Vis-NIR Fluorescence Dyes and Developing a Laser Induced Fluorescence Capillary Zone Electrophoresis (LIF-CZE) Technique to Study Alkanesulfonate Monooxygenase, Garfield Beckford

Mechanistic Enzymology of Flavin-dependent Catalysis in Bacterial D-Arginine Dehydrogenase and Choline Oxidase, Swathi Gannavaram

Heme-dependent Tryptophan Oxidation: Mechanistic Studies on Tryptophan 2,3-Dioxygenase and MauG, Jiafeng Geng

Synthesis of Aza-Heterocyclic Monoamidines as Potential DNA Minor Groove Binders, Anti-Trypanosomals, and Boron Neutron Capture Therapy Agents, Julius Green

Detection and inhibition of influenza using synthetic sialosidesc, Yun He

Structural and Mechanistic Studies on à-Amino ?-Carboxymuconate î-Semialdehyde Decarboxylase and à-Aminomuconate î-Semialdehyde Dehydrogenase, Lu Huo

Novel Selenium-modified Nucleic Acids For Structural and Functional Studies, Sibo Jiang

Using Molecular Dynamics to Elucidate the Mechanism of Cyclophilin, Lauren McGowan

Development of Novel Protein-Based MRI Contrast Agents for the Molecular Imaging of Cancer Biomarkers, Fan Pu

Atom-Specific Modification of Uracil Bases with Selenium for RNA Structure and Function Studies, Huiyan Sun

Molecular Dynamics Simulations Towards The Understanding of the Cis-Trans Isomerization of Proline As A Conformational Switch For The Regulation of Biological Processes, Hector Velazquez

From "Click" to "Click and Release", Using Inverse Electron Demand Diels-Alder Reaction for Chemical and Medicinal Applications, Danzhu Wang

One DNA minor groove, many possibilities: from sequence recognition to transcription factor inhibition, Shuo Wang

Cleavage of Lipids and DNA by Metal Ions and Complexes, Dominique Williams

"Coarse Grained" Bead Modeling of Macromolecules Transport in Free Solution and in a Gel, Hengfu Wu

Modeling Assemblies and Interactions at the Replication Fork: Sliding Clamps and Clamp Interacting Enzymes, Xiaojun Xu

Integration Of Extracellular And Intracellular Signals Via The Calcium Sensing Receptor (CASR), Chen Zhang

Dissertations from 2013 2013

Design and Synthesis of HIF-1 Inhibitors as Anti-cancer Therapeutics, Sarah Burroughs

Inhibitors of SecA as Potential Antimicrobial Agents, Arpana S. Chaudhary

The Structure and Function Study of Three Metalloenzymes That Utilize Three Histidines as Metal Ligands, Yan Chen

Development of RNA Microchip for Pathogen and Cancer Direct Detection, Lilian W. Kamau-Gatogo

Molecular Probe Designs For Nucleic Acid Based Detection, Manindar Kaur

A Structural and Mechanistic Study of Two Members of Cupin Family Protein, Fange Liu

DNA Interactions and Photocleavage by Anthracene, Acridine, and Carbocyanine-Based Chromophores, Carla Mapp

Enzymatic Mechanisms and Chemical Probes of the Myst Family of Histone Acetyltransferases, Chao Yang

Macromolecular Interactions in West Nile Virus RNA-TIAR Protein Complexes and of Membrane Associated Kv Channel Peptides, Jin Zhang

Crystallographic Study of HIV Protease Drug Resistant Variants and Green Fluorescent Protein Based Calcium Sensor CatchER, Ying Zhang

Modulating Calcium Signaling by Protein Design and Analysis of Calcium Binding Proteins, You Zhuo

Dissertations from 2012 2012

Characterization of the HEME Uptake Pathway Proteins from Streptococcus Pyogenes and Corynebacterium Diphtheriae, Neval Akbas

Development of Antimicrobial Agent with Novel Mechanisms of Actions and 1,2,4,5-Tetrazine Click Chemistry and its Application in DNA Postsynthetic Functionalization, Weixuan Chen

Dissecting Key Determinants for Calcium and Calmodulin Regulation of GAP Junction and Viral Protein, Yanyi Chen

Kinetic Mechanism and Inhibitory Study of Protein Arginine Methyltransferase 1, You Feng

Biophysical Characterization of the Binding of Homologous Anthraquinone Amides to DNA, Shirlene R. Jackson Beckford

Calcium Modulates MGLUR1 Folding in ER in the Trafficking Process and Regulates the Drug Activity Upon the Receptor Expressing on the Cell Membrane, Yusheng Jiang

Electrochemical Characterizations and Theoretical Simulations of Transport Behaviors at Nanoscale Geometries and Interfaces, Juan Liu

Development of Bacterial Quorum Sensing Inhibitors and Molecular Probes, Hanjing Peng

Biophysical Characterization of Synthetic Imidazole and Pyrrole Containing Analogues of Netropsin and Distamycin that Target Specific DNA Sequences for the Treatment of Various Diseases, Joseph P. Ramos

Modulation and Recognition of Nucleic Acid Structures, Alexander M. Spring

Rational Design and Application of Genetically Encoded Fluorescent Reporters in Cellular Physiology, Shen Tang

Structure and Function Studies of Selenium Substituted Nucleic Acids, Wen Zhang

Synthesis and Energetics of Gold Nanoclusters Tailored by Interfacial Bonding Structure, Tang Zhenghua

Dissertations from 2011 2011

I. Synthesis Of Anthraquinone Derivatives For Electron Transfer Studies In DNA. II. Characterization Of The Interaction Between Heme And Proteins., Yu Cao

Development of Boronic Acid Flurescent Reporters, Boronic Acid-Modified Thymidine Triphosphates for Sensor Design and Antagonists of Bacterial Quorum Sensing in Vibrio Harveyi, Yunfeng Cheng

Novel Near-Infrared Cyanine Dyes for Fluorescence Imaging in Biological Systems, Nilmi T. Fernando

On the Biochemistry, Mechanism and Physiological Role of Fungal Nitronate Monooxygenase, Kevin Francis

Chiral Analysis Using Capillary Electrophoresis Coupled to Mass Spectrometry: Development of Novel Modes and Applications Using Molecular Micelles and Surfactant-Bound Monolithic Columns, Jun He

Tuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent, Jie Jiang

Nucleic Acid Substrates: Investigation of Structural and Dynamic Features that Influence Enzyme Activity, Christopher N. Johnson

Defining a Molecular Mechanism for Lead Toxicity via Calcium-Binding Proteins, Michael Kirberger

Targeted Molecular MR Imaging of HER2 and EGFR Using De Novo Designed Protein Contrast Agents, Jingjuan Qiao

Protein-Nucleic Acid Interactions in Nuclease and Polymerases, abdur rob

Development of Inhibitors and Assay Methods for Histone Acetyltransferases, Jiang Wu

Mechanistic Studies of Two Selected Flavin-Dependent Enzymes: Choline Oxidase and D-Arginine Dehydrogenase, Hongling Yuan

Dissertations from 2010 2010

Synthesis of Fused Heterocyclic Diamidines for the Treatment of Human African Trypanosomiasis and Fluorescence Studies of Selected Diamidines, Jennifer Crystal Brown Barber

Rational Drug Design for Neglected Diseases: Implementation of Computational Methods to Construct Predictive Devices and Examine Mechanisms, Catharine Jane Collar

Roles of Serine 101, Histidine 310 and Valine 464 in the Reaction Catalyzed by Choline Oxidase from Arthrobacter Globiformis, Steffan Finnegan

Design and Synthesis of Novel Serotonin Receptor Ligands, Jeffrey D. Klenc

Design, Synthesis and Mechanistic Studies of Small Molecule Inhibitors of the Hypoxia Inducible Factor Pathway, Suazette Reid Mooring

Sequence-Specific and Conformation-Specific Targeting of Duplex and Quadruplex DNA Grooves with Small Molecules, Rupesh K. Nanjunda

Application of Boronic Acids in Medicinal Chemistry (Inhibitors, Sensors), Nanting Ni

Bead Modeling of Transport Properties of Macromolecules in Free Solution and in a Gel, Hongxia Pei