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Theses from 2024

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Synthesis of Novel Tryptophan Drug Candidates for Thera(g)nositcs for the Human Calcium Receptor, Matthew Goodman

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Synthesis, Characterization and Optical Properties of New NIR Donor Acceptor Fluorophores for Potential Biomedical Applications, Zaryab Gul

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Exploring Calcium Sensing Mechanisms via the Calcium Sensing Receptor, Oluwadamilola Rosemary Ilupeju

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Exploration of the Molecular Mechanisms of E3 Ligases RNF216, Rsp5, Parkin and their Novel Substrates Elucidated by the Orthogonal Ubiquitin Transfer Cascade, Savannah E. Jacobs

Theses from 2023

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Insights into the Local Structural Impact of Ribonucleotide Inclusion in Duplexed DNA, Steven T. Brenden

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Catalytic Production of Carbon Monoxide from Phenyl Pyruvic Acid: Possible Therapeutic and Diagnostic Applications, Rujuta Ghorpade

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Optimization of the Purification and Formation of hProCA32 for Human Clinical Application, Hyein Kang

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The Production of DNA Damaging Reactive Oxygen Species (ROS) by Some Natural Products: A Comparative Analysis, Erhunmwense Obayuwana

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Synthesis and Optical Properties of Red Shifted Squaraine Dyes Containing Perimidine Moiety as Potential Optoacoustic Imaging Agents, Shahir Sarasiya

Theses from 2022

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Negative Differential Resistance in The Rectified Ion Transport Hysteresis in Single Conical Nanopipettes, Yusuff Mobolaji Balogun

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Bioreversible Derivatization of Drug Molecules with a Pyridine Ring for Improved Water Solubility: Model Studies, Shubham Bansal

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Investigation into Novel Mitochondrial Targeting Cyanine Dyes as Potential Photosensitizing Agents for Photodynamic Therapy, David Brewer

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Ultrabright Fluorine Containing Squaraine Fluorophores Used for Biological Imaging, Stefanie Casa

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Synthesis and Characterization of Carbon Monoxide Prodrugs, David B. Cohen

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Synthesis and Optical Properties of Near Infrared Donor-ᴫ-Acceptor Fluorophores for Bioimaging Applications, Ranju Ghimire

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Profiling Substrates of HECT and U-box E3 Ligases via Orthogonal Ubiquitin Transfer Cascade and Mimicking the Activity of HECT E3 Ligase with a â-AA Peptide, Geon Jeong

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Engineering an Orthogonal Ubiquitin Transfer (OUT) Cascade for Cbl-b, an E3 Ubiquitin Ligase Regulating Innate Immunity against Cancer Cells and Inhibition of the ubiquitin-proteasome system by peptidomimetic foldamer mimicking E2 N-terminal-helix, In Jeong

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Calcium Sensing Via The Calcium-Sensing Receptor and Designed Calcium Sensors, Cheyenne T. McBean

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Formulation and Production of Collagen Targeting Protein MRI Contrast Agent for Early Detection of Liver Cancer and fibrosis, Brenda-Ruth Mimba

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Mechanistic Investigation of a Non-Catalytic Gating Residue in NADH:Quinone Oxidoreductase from Pseudomonas aeruginosa PA01, Bilkis Mehrin Moni

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Dye-Sensitized DNA Photocleavage Facilitated by Donor-Acceptor Fluorophores in the NIR Wavelength Range, Carine Seudieu

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Synthesis, and Characterization of Hemicyanine Dyes as Potential Contrast Agents for Photoacoustic Imaging, Tuyen Tran

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Enzyme Kinetics and Structural Studies of Drug Resistant HIV Protease, Sarah R. Verhoff

Theses from 2021

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Genomic Epidemiology Analysis of SARS-CoV-2 Transmission Dynamics in Belarus, Ayotomiwa Ezekiel Adeniyi

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Mechanistic Characterization of Active Site Residues in Nitronate Monooxygenase from Pseudomonas aeruginosa PAO1, Christopher Aguillon

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Unprecedented DNA Photocleavage Mediated by Quinolinium Pentamethine Carbocyanine Dyes in the NIR Wavelength Range, Effibe O. Ahoulou

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A Comparative Study of Oxycyclobutenolate vs Dicyanomethylene Squaraine Dyes: Synthesis, Photophysical Properties and Biological Imaging Application, Babatunde N. Animasaun

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Functional Importance of Non-Catalytic Residues in the Active Site of NADH:Quinone Oxidoreductase From Pseudomonas aeruginosa PA01, Benjamin Dratch and Gioavanni Gadda

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Synthesis and Optical Properties of Red Shifted Donor Acceptor Fluorophores as Potential Agents for Biomedical Applications, Guliz Ersoy Ozmen

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Calculated Vibrational Properties of Asymmetrically Hydrogen Bonded Benzoquinones and Naphthoquinones, Mohammadnabi Ilanikashkouli

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Enhancement of Anti-tumor Efficacy of an Armed Oncolytic Virus: VSV-SKPC, Breona Luker

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Separation of Short and Medium-Chain Fatty Acids Using Capillary Electrophoresis with Indirect Photometric Detection, Uyen Pham

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An Experimental Benchmark Set for Oscillator Strength Calculations of Small to Medium-sized Organic Molecules, Astrid Tarleton

Theses from 2020

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Characterization of Heme Binding to PEFR, A Marr Transcriptional Regulator, Rosemary Andrews

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An Innovative Way To Synthesize 2'-SeMeANA-U AND 2'-SeMeANA-C, Mohammad Sazid Hassan

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Investigating the Role of Hydration and DNA Dynamic Alterations in DNA Recognition by A Heterocyclic Diamidine, Van Ha

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Synthesis, Characterization, Optical Properties and DNA Cleavage Study of Symmetrical Pentamethine Cyanine Dyes Containing Quinoline Moieties, Kristina Ilina

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The Synthesis and Optical Properties of the Squaraine Scaffold and Ph Responsive Cyanine Dyes Containing Pyridine at the Meso-Carbon, Wheeler R. Lovett

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Simulation of Photoelectron Spectra of Small Organic Molecules, MD Mahbub

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Characterization of Heme Uptake Proteins; HtaB, ChtB, and ChtA from Corynebacterium Diphtheriae Approaches to the Reaction of Dechloromonas Aromatica Chlorite Dismutase with Nitrite, Catherine Odhiambo

Theses from 2019

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Biophysical Properties of DNA Minor Groove Binding by Heterocyclic Cations of Varying Structures, Noa Erlitzki

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Photoelectron Spectra and Formation Mechanisms of Interstellar C3H2O Isomers from Quantum Mechanical Calculations, Rebecca Johnson

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Synthesis and Crystallization Study of the 5-Se-Thymidine DNAs and the Complexes with Small Molecules, Shuo Liu

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Exploring the Dynamics of Glycolytic Regulation Through Two Enzymes: Human Enolase and Liver Pyruvate Kinase, Abdullah Shouaib

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Synthesis and Properties of Lipoic Acid Stabilized Gold Nanoclusters, Minh Tri Tran

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Kinetic Viscosity Effects Reveal a Protein Isomerization in the Reductive Half-Reaction of Nitronate Monooxygenase, Maria Vodovoz

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Computational Study on Protein Arginine methyl-transferases (PRMTs), Zhenyu Wang

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Enhanced Electrochemiluminescence and Current Signals from Metal Nanoclusters and Their Surface Assemblies by Prototype Tertiary Amines, Meijun Yi

Theses from 2018

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Atomic Resolution X-Ray Crystal Structure of HIV-1 Protease in Complex with Atazanavir, Andrew N. Baumert

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Elucidating Ubiquitin Chain Formation Catalyzed by E2 Enzymes through use of a Di-Ubiquitin Probe, Tomaya Carpenter

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Investigation of Low-Temperature Effects on DNA Photocleavage Using a Novel Thioether Substituted Cyanine Dye, Andrew Clay

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Improvement Of Vesicular Stomatitis Virus In Order To Enhance Its Oncolytic Effects, Zahra Enadi

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Characterizing the Heme Uptake Proteins HtaB and ChtB in Corynebacterium diphtheriae, Brandon L. Ferrell

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Understanding Integrase-DNA Interactions in Retroviruses Through 3'-processing, Zachary E. Ferris and Markus W. Germann

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Synthesis and Photophysical Properties of Phenoxazine Analogs Designed as Potential Antimalarials, Carl Mufungwa Kananda

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The Utilization of Alternative Synthetic Methods for Further Optimization of Cyanine Dyes and their Potential Use in Imaging and Photodynamic Therapy, Fahad Marmarchi

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The Energetics and Reversibility of Oxyanions Adsorption/Desorption on Pure and Aluminium-Substituted Ferrihydrite, Alireza Namayandeh

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Determination of Mouth-level Exposure to Catechol in Mainstream Cigarette Smoke, Phuong K. Ngac

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Determining xE2-xE3 Pair of RNF38 by Phage Display for Orthogonal Ubiquitin Transfer, Nicolas Rios

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Synthesis and Analysis of Pyridine Derivatives as Small Molecule Antagonists of CXCR4, Saniya Virani

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Temperature Screening Of Trisaccharide (GlcNAc?1, 3Gal?1, 4Glc) Synthesis In Recombinant Escherichia Coli By Fermentation, Chi Zhang

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A Novel Method for Synthesis of 2'-SeMeANA-dT, Lingrui Zheng

Theses from 2017

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Pirin Allosterically Modulates The Dynamics And Interactions Of The Kappa B DNA In The NF-Kappa B Supramolecular Complex, Charles Adeniran

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Organic Carbon Monoxide Prodrugs, Robert Aghoghovbia

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Cation Adsorption and Exchange at the Mineral-Water Interface: The Role of Hydration and Hydrolysis, Nicholas Allen

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Insulin Nucleation Using Voltage Clamping and Current Clamping Techniques, Michael J. Bowen

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Synthesis Of Novel Organic Carbon Monoxide Prodrugs With Tunable Release For Biological Applications, Vayou Chittavong

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Analysis Of DNA Interactions and Photocleavage by Phenyl Meso Substituted Cyanine Dyes In The Near-Infrared Range, Christina Fischer

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Cloning, Purification, and Biochemical Characterization of PA1225, a Novel FAD Containing NADPH:Quinone Reductase from Pseudomonas aeruginosa PAO1, Elias Flores

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Synthesis & Evaluation Of Thiophene Derivatives As CXCR4 Antagonists, Francisco Javier Garcia Jr.

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Investigation and Characterization of Novel Pentamethine Cyanine Dyes for Use as Photosensitizers in Photodynamic Therapy, Kaitlyn Kiernan

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Atomistic Insights into Binding Pocket Dynamics and Regulation in the Interleukin-2 T-Cell Kinase SH2 Domain, Mohamed Momin

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DNA Encoded Libraries (DEGL) of Glycan Antigens to Detect Antibodies: An Approach Towards Next Generation Functional Glycomics, Aishwarya Parameswaran

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Computational Studies of Liver Receptor Homolog 1 in the Presence of Small Molecule Agonists: Allosteric Communication and Virtual Screening for New Potential Drug Candidates, Bernard Scott Jr

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Biophysical Heme Binding Studies of Corynebacterium diphtheriae and Streptococcus pyogenes, Stephanie Thompson

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Determination of Dynamical Conservation in Human Cyclophilin Isoforms, Phuoc Jake D. Vu

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Design and Synthesis of Inhibitors of Hypoxia Inducible Factor-1-mediated Functions, Lingyun Yang

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Chemoenzymatic Synthesis of UDP-GlcNAc and UDP-GalNAc Derivatives for Chemoenzymatic Labeling, Yuan Zheng

Theses from 2016

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Synthesis of 2SeU-RNAs and RNA Squares, Xinghua Chen

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Synthesis and Determination of Optical Properties of Selected Pentamethine Carbocyanine Dyes, Tyler L. Dost

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DNA Photo-Cleavage and Interactions by Quinoline Cyanine Dyes; Towards Improving Photodynamic Cancer Therapy, Tayebeh Fatemipouya

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Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes, Demesheka Goolsby

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Spectroscopic and Thermodynamic Characterization of Human 3-Hydroxyanthranilate-3,4-Dioxygenase, Calmour Henry

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Synthetic Development of Cyanine Dyes and Investigation of Their Interaction with Duplex DNA, Cory Holder

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Study Of The DNA Packaging Protein From A Phage That Replicates Under Extreme Conditions, Philip Lessans

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Exploring HIV Integrase 3'-processing Using Designed DNA Substrates and Structural Study of HIV DNA Hairpins, Qiushi Li

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Modifications To The Benzophenoxazine Architecture: Synthesis And Characterization, Vincent Martinez

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An Investigation of the DNA Interactions of Polyamine Anthracene Conjugates under High Ionic Conditions, Khoa Nguyen

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Establishing the Relationship Between Function and Dynamics Within the Gated Mechanism of D-arginine Dehydrogenase, Michael Souffrant

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Investigation Of A Novel Mammalian Thiol Dioxygenase Structure: Human Cysteamine Dioxygenase, Tseng Xiong and Tseng Xiong

Theses from 2015

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Discovery of Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Using in silico Virtual Screening & Network Analysis for Evolution of Allosteric Communication in 3-ketosteroid Receptors, Shih-Wei Chuo

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A Novel Method for Bioanalysis of Dye Covalently Encapsulated in Silica Nanoparticles and Characterization of NIR Dyes for Future Approach, Kyle Emer

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Cyanine Dyes Targeting G-quadruplex DNA: Significance in Sequence and Conformation Selectivity, Hang T. Huynh

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Spectroscopic Studies of Cyanine Dyes and Serum Albumins for Bioanalytical Applications, Erica Lewis

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An Investigation of Autoxidation and DNA Thermal Cleavage by Polymethine Cyanine Dyes and Analogs in Aqueous Solutions, Ziyi Li

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Synthesis of Sulfated Polysaccharides for Colitis Mice Model, Qiang Ma

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Observation Of Spectral Changes To Trp-214 Residue In Human Serum Albumin Upon Binding With Mangiferin And Near Infrared Dyes, Jennifer Novak

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Mechanistic Investigation of the Flavin-Neighboring Residues S45, A46 and I335 in Pseudomonas aeruginosa D-arginine Dehydrogenase, Daniel Ouedraogo and Gioavanni Gadda

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Development of New Series of Protein Based MRI Contrast Agents: ProCA1 Variants and Humanized ProCA32, Anvi N. Patel

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Protein Modification of Designed MRI Contrast Agents, Corrie N. Purser